Cholinesterase inhibitors from the roots of Harpagophytum procumbens

Yoon Ho Bae, To Dao Cuong, Tran Manh Hung, Jeong Ah Kim, Mi Hee Woo, Jeong Su Byeon, Jae Sue Choi, Byung Sun Min

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22 Scopus citations

Abstract

Inhibition of cholinesterase has been proposed to be a therapeutic target for the treatment of Alzheimer's diseases. In our preliminary screening study on the acetylcholinesterase (AChE) inhibitory activity, an ethyl acetate soluble fraction of the roots of Harpagophytum procumbens (Pedaliaceae) was found to inhibit AChE activity at the concentration of 100 μg/mL. Ten compounds (1-10) were isolated from the active fraction and evaluated for their inhibitory effect on AChE and butyrylcholinesterase (BChE). Among the isolates, verbascosides (5, 6, and 8) containing a caffeoyl and a 3,4-dihydroxyphenethyl groups in their structures, showed effective AChE inhibitory activity and also possessed BChE inhibitory activity. The findings suggest that verbascoside derivatives may be partially related to the anti-Alzheimer effect of this medicinal plant.

Original languageEnglish
Pages (from-to)1124-1129
Number of pages6
JournalArchives of Pharmacal Research
Volume37
Issue number9
DOIs
StatePublished - Sep 2014

Keywords

  • AChE
  • Anti-Alzheimer effects
  • BChE
  • Harpagophytum procumbens
  • Pedaliaceae

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