Chronological changes in pyridoxine-5′-phosphate oxidase immunoreactivity in the seizure-sensitive gerbil hippocampus

Tae Cheon Kang; Seung Kook Park; In Koo Hwang; Sung Jin An; Jae Hoon Bahn; A. Yeon Kim; Soo Young Choi; Oh Shin Kwon; Nam In Baek; Hyeon Yong Lee; Moo Ho Won

doi:10.1002/jnr.10280

Chronological changes in pyridoxine-5′-phosphate oxidase immunoreactivity in the seizure-sensitive gerbil hippocampus

Tae Cheon Kang, Seung Kook Park, In Koo Hwang, Sung Jin An, Jae Hoon Bahn, A. Yeon Kim, Soo Young Choi, Oh Shin Kwon, Nam In Baek, Hyeon Yong Lee, Moo Ho Won

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16 Scopus citations

Abstract

To identify the roles of pyridoxine-5′-phosphate (PNP) oxidase in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PNP oxidase expression was conducted. PNP oxidase immunoreactivity in a preseizure group of seizure-sensitive (SS) gerbils was detected more strongly than that in a seizure-resistant (SR) group. The density of PNP oxidase immunoreactivity in a 30 min postictal group was significantly lower than that in a preseizure group. In a 12 hr postictal group, PNP oxidase immunodensity had recovered to a preseizure level. The overexpression of PNP oxidase in the hippocampus of preseizure SS gerbils suggests that PNP or pyridoxal 5′-phosphate plays an important role in the modulation of glutamic acid decarboxylase activity and γ-aminobutyric acid reuptake as mediated by membrane transporter via neurons. In addition, this change in the PNP oxidase immunoreactivity following seizure may be a compensatory response designed to reduce epileptic activity in this animal.

Original language	English
Pages (from-to)	785-791
Number of pages	7
Journal	Journal of Neuroscience Research
Volume	68
Issue number	6
DOIs	https://doi.org/10.1002/jnr.10280
State	Published - 15 Jun 2002

Keywords

Epileptogenesis
Gerbil
Hippocampus
Pyridoxal 5′-phosphate
Pyridoxal kinase
Seizure

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title = "Chronological changes in pyridoxine-5′-phosphate oxidase immunoreactivity in the seizure-sensitive gerbil hippocampus",

abstract = "To identify the roles of pyridoxine-5′-phosphate (PNP) oxidase in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PNP oxidase expression was conducted. PNP oxidase immunoreactivity in a preseizure group of seizure-sensitive (SS) gerbils was detected more strongly than that in a seizure-resistant (SR) group. The density of PNP oxidase immunoreactivity in a 30 min postictal group was significantly lower than that in a preseizure group. In a 12 hr postictal group, PNP oxidase immunodensity had recovered to a preseizure level. The overexpression of PNP oxidase in the hippocampus of preseizure SS gerbils suggests that PNP or pyridoxal 5′-phosphate plays an important role in the modulation of glutamic acid decarboxylase activity and γ-aminobutyric acid reuptake as mediated by membrane transporter via neurons. In addition, this change in the PNP oxidase immunoreactivity following seizure may be a compensatory response designed to reduce epileptic activity in this animal.",

keywords = "Epileptogenesis, Gerbil, Hippocampus, Pyridoxal 5′-phosphate, Pyridoxal kinase, Seizure",

author = "Kang, {Tae Cheon} and Park, {Seung Kook} and Hwang, {In Koo} and An, {Sung Jin} and Bahn, {Jae Hoon} and Kim, {A. Yeon} and Choi, {Soo Young} and Kwon, {Oh Shin} and Baek, {Nam In} and Lee, {Hyeon Yong} and Won, {Moo Ho}",

year = "2002",

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AU - Kang, Tae Cheon

AU - Park, Seung Kook

AU - Hwang, In Koo

AU - An, Sung Jin

AU - Bahn, Jae Hoon

AU - Kim, A. Yeon

AU - Choi, Soo Young

AU - Kwon, Oh Shin

AU - Baek, Nam In

AU - Lee, Hyeon Yong

AU - Won, Moo Ho

PY - 2002/6/15

Y1 - 2002/6/15

N2 - To identify the roles of pyridoxine-5′-phosphate (PNP) oxidase in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PNP oxidase expression was conducted. PNP oxidase immunoreactivity in a preseizure group of seizure-sensitive (SS) gerbils was detected more strongly than that in a seizure-resistant (SR) group. The density of PNP oxidase immunoreactivity in a 30 min postictal group was significantly lower than that in a preseizure group. In a 12 hr postictal group, PNP oxidase immunodensity had recovered to a preseizure level. The overexpression of PNP oxidase in the hippocampus of preseizure SS gerbils suggests that PNP or pyridoxal 5′-phosphate plays an important role in the modulation of glutamic acid decarboxylase activity and γ-aminobutyric acid reuptake as mediated by membrane transporter via neurons. In addition, this change in the PNP oxidase immunoreactivity following seizure may be a compensatory response designed to reduce epileptic activity in this animal.

AB - To identify the roles of pyridoxine-5′-phosphate (PNP) oxidase in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PNP oxidase expression was conducted. PNP oxidase immunoreactivity in a preseizure group of seizure-sensitive (SS) gerbils was detected more strongly than that in a seizure-resistant (SR) group. The density of PNP oxidase immunoreactivity in a 30 min postictal group was significantly lower than that in a preseizure group. In a 12 hr postictal group, PNP oxidase immunodensity had recovered to a preseizure level. The overexpression of PNP oxidase in the hippocampus of preseizure SS gerbils suggests that PNP or pyridoxal 5′-phosphate plays an important role in the modulation of glutamic acid decarboxylase activity and γ-aminobutyric acid reuptake as mediated by membrane transporter via neurons. In addition, this change in the PNP oxidase immunoreactivity following seizure may be a compensatory response designed to reduce epileptic activity in this animal.

KW - Epileptogenesis

KW - Gerbil

KW - Hippocampus

KW - Pyridoxal 5′-phosphate

KW - Pyridoxal kinase

KW - Seizure

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JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

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ER -

Chronological changes in pyridoxine-5′-phosphate oxidase immunoreactivity in the seizure-sensitive gerbil hippocampus

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