Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells

Bui Huu Tai; Nguyen Manh Cuong; Tran Thu Huong; Eun Mi Choi; Jeong Ah Kim; Young Ho Kim

doi:10.1080/10286020903117317

Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells

Bui Huu Tai, Nguyen Manh Cuong, Tran Thu Huong, Eun Mi Choi, Jeong Ah Kim, Young Ho Kim

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.

Original language	English
Pages (from-to)	817-823
Number of pages	7
Journal	Journal of Asian Natural Products Research
Volume	11
Issue number	9
DOIs	https://doi.org/10.1080/10286020903117317
State	Published - Sep 2009

Keywords

Anti-osteoporosis
Chrysoeriol
Eurya ciliata
MC3T3-E1 cell

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10.1080/10286020903117317

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title = "Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells",

abstract = "Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.",

keywords = "Anti-osteoporosis, Chrysoeriol, Eurya ciliata, MC3T3-E1 cell",

author = "Tai, {Bui Huu} and Cuong, {Nguyen Manh} and Huong, {Tran Thu} and Choi, {Eun Mi} and Kim, {Jeong Ah} and Kim, {Young Ho}",

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AU - Tai, Bui Huu

AU - Cuong, Nguyen Manh

AU - Huong, Tran Thu

AU - Choi, Eun Mi

AU - Kim, Jeong Ah

AU - Kim, Young Ho

PY - 2009/9

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N2 - Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.

AB - Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.

KW - Anti-osteoporosis

KW - Chrysoeriol

KW - Eurya ciliata

KW - MC3T3-E1 cell

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Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells

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