Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells

Bui Huu Tai; Nguyen Manh Cuong; Tran Thu Huong; Eun Mi Choi; Jeong Ah Kim; Young Ho Kim

doi:10.1080/10286020903117317

Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells

Bui Huu Tai
, Nguyen Manh Cuong
, Tran Thu Huong
, Eun Mi Choi
, Jeong Ah Kim
, Young Ho Kim

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.

Original language	English
Pages (from-to)	817-823
Number of pages	7
Journal	Journal of Asian Natural Products Research
Volume	11
Issue number	9
DOIs	https://doi.org/10.1080/10286020903117317
State	Published - Sep 2009

Keywords

Anti-osteoporosis
Chrysoeriol
Eurya ciliata
MC3T3-E1 cell

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10.1080/10286020903117317

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title = "Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells",

abstract = "Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.",

keywords = "Anti-osteoporosis, Chrysoeriol, Eurya ciliata, MC3T3-E1 cell",

author = "Tai, \{Bui Huu\} and Cuong, \{Nguyen Manh\} and Huong, \{Tran Thu\} and Choi, \{Eun Mi\} and Kim, \{Jeong Ah\} and Kim, \{Young Ho\}",

year = "2009",

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doi = "10.1080/10286020903117317",

language = "English",

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T1 - Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells

AU - Tai, Bui Huu

AU - Cuong, Nguyen Manh

AU - Huong, Tran Thu

AU - Choi, Eun Mi

AU - Kim, Jeong Ah

AU - Kim, Young Ho

PY - 2009/9

Y1 - 2009/9

N2 - Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.

AB - Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.

KW - Anti-osteoporosis

KW - Chrysoeriol

KW - Eurya ciliata

KW - MC3T3-E1 cell

UR - https://www.scopus.com/pages/publications/70449657095

U2 - 10.1080/10286020903117317

DO - 10.1080/10286020903117317

M3 - Article

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AN - SCOPUS:70449657095

SN - 1028-6020

VL - 11

SP - 817

EP - 823

JO - Journal of Asian Natural Products Research

JF - Journal of Asian Natural Products Research

IS - 9

ER -

Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells

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