Cinnamaldehydes in Cancer Chemotherapy

Su Hyung Hong, Ismail Ahmed Ismail, Sung Min Kang, Dong Cho Han, Byoung Mog Kwon

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations

Abstract

Cinnamaldehyde and cinnamaldehyde-derived compounds are candidates for the development of anticancer drugs that have received extensive research attention. In this review, we summarize recent findings detailing the positive and negative aspects of cinnamaldehyde and its derivatives as potential anticancer drug candidates. Furthermore, we describe the in vivo pharmacokinetics and metabolism of cinnamaldehydes. The oxidative and antioxidative properties of cinnamaldehydes, which contribute to their potential in chemotherapy, have also been discussed. Moreover, the mechanism(s) by which cinnamaldehydes induce apoptosis in cancer cells have been explored. In addition, evidence of the regulatory effects of cinnamaldehydes on cancer cell invasion and metastasis has been described. Finally, the application of cinnamaldehydes in treating various types of cancer, including breast, prostate, and colon cancers, has been discussed in detail. The effects of cinnamaldehydes on leukemia, hepatocellular carcinoma, and oral cancer have been summarized briefly.

Original languageEnglish
Pages (from-to)754-767
Number of pages14
JournalPhytotherapy Research
Volume30
Issue number5
DOIs
StatePublished - 1 May 2016

Keywords

  • 2′-benzoyloxycinnamaldehyde
  • 2′-hydroxycinnamaldehyde
  • apoptosis
  • cancer chemotherapy
  • cinnamaldehyde

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