Circling mouse, a spontaneous mutant in the inner ear

Jeong Woong Lee, Zae Young Ryoo, Eun Ju Lee, Sung Hwa Hong, Won Ho Chung, Hoon Taek Lee, Kil Saeng Chung, Tae Yoon Kim, Yang Seok Oh, Jun Gyo Suh

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

A spontaneous mutant was established in the ICR mouse strain. The affected mice became hyperactive at about 7 days of age, and then showed circling behavior. The body weight decreased significantly 2 weeks after birth, and developmental defects were revealed in the middle ear, cochlea, cochlear nerve, and semicircular canal areas. The mutation was inherited by an autosomal single recessive gene and is referred to as cir.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalExperimental Animals
Volume51
Issue number2
DOIs
StatePublished - Apr 2002

Keywords

  • Circling mouse
  • Inner ear
  • Organ of Corti

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