Clinical Implications of Mismatch Repair Status in Patients With High-risk Stage II Colon Cancer

Dong Won Baek; Byung Woog Kang; Soo Jung Lee; Hye Jin Kim; Su Yeon Park; Jun Seok Park; Gyu Seog Choi; Jin Ho Baek; Jong Gwang Kim

doi:10.21873/invivo.11523

Clinical Implications of Mismatch Repair Status in Patients With High-risk Stage II Colon Cancer

Dong Won Baek, Byung Woog Kang, Soo Jung Lee, Hye Jin Kim, Su Yeon Park, Jun Seok Park, Gyu Seog Choi, Jin Ho Baek, Jong Gwang Kim

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background/Aim: This study evaluated the clinical significance of the mismatch repair (MMR) status and prognostic factors in patients with high-risk stage II colon cancer (CC). Materials and Methods: This was a retrospective analysis of 237 patients diagnosed with high-risk stage II CC who had test results for MMR status. Results: Among the 237 patients, 76 (32.1%) were identified as having a microsatellite instability-high (MSI-H) status. No significant differences were identified in disease-free or overall survival according to the MMR status. Moreover, no association was found between the use of adjuvant chemotherapy and survival outcomes of the MSI-H group. In a multivariate survival analysis, the primary tumor location (right-sided versus left-sided, hazard ratio(HR)=0.172, p=0.003) and T-stage (HR=4.764, p=0.005) were identified as independent prognostic factors for disease-free survival. Conclusion: The present study found that the MMR status was neither prognostic nor predictive in patients with high-risk stage II CC.

Original language	English
Pages (from-to)	649-657
Number of pages	9
Journal	In Vivo
Volume	33
Issue number	2
DOIs	https://doi.org/10.21873/invivo.11523
State	Published - Mar 2019

Keywords

Adjuvant chemotherapy
High-risk features
Mismatch repair
Stage II colon cancer

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10.21873/invivo.11523

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@article{455ec3a879324082a31fe502c057dcb2,

title = "Clinical Implications of Mismatch Repair Status in Patients With High-risk Stage II Colon Cancer",

abstract = "Background/Aim: This study evaluated the clinical significance of the mismatch repair (MMR) status and prognostic factors in patients with high-risk stage II colon cancer (CC). Materials and Methods: This was a retrospective analysis of 237 patients diagnosed with high-risk stage II CC who had test results for MMR status. Results: Among the 237 patients, 76 (32.1%) were identified as having a microsatellite instability-high (MSI-H) status. No significant differences were identified in disease-free or overall survival according to the MMR status. Moreover, no association was found between the use of adjuvant chemotherapy and survival outcomes of the MSI-H group. In a multivariate survival analysis, the primary tumor location (right-sided versus left-sided, hazard ratio(HR)=0.172, p=0.003) and T-stage (HR=4.764, p=0.005) were identified as independent prognostic factors for disease-free survival. Conclusion: The present study found that the MMR status was neither prognostic nor predictive in patients with high-risk stage II CC.",

keywords = "Adjuvant chemotherapy, High-risk features, Mismatch repair, Stage II colon cancer",

author = "Baek, {Dong Won} and Kang, {Byung Woog} and Lee, {Soo Jung} and Kim, {Hye Jin} and Park, {Su Yeon} and Park, {Jun Seok} and Choi, {Gyu Seog} and Baek, {Jin Ho} and Kim, {Jong Gwang}",

year = "2019",

month = mar,

doi = "10.21873/invivo.11523",

language = "English",

volume = "33",

pages = "649--657",

journal = "In Vivo",

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publisher = "International Institute of Anticancer Research",

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T1 - Clinical Implications of Mismatch Repair Status in Patients With High-risk Stage II Colon Cancer

AU - Baek, Dong Won

AU - Kang, Byung Woog

AU - Lee, Soo Jung

AU - Kim, Hye Jin

AU - Park, Su Yeon

AU - Park, Jun Seok

AU - Choi, Gyu Seog

AU - Baek, Jin Ho

AU - Kim, Jong Gwang

PY - 2019/3

Y1 - 2019/3

N2 - Background/Aim: This study evaluated the clinical significance of the mismatch repair (MMR) status and prognostic factors in patients with high-risk stage II colon cancer (CC). Materials and Methods: This was a retrospective analysis of 237 patients diagnosed with high-risk stage II CC who had test results for MMR status. Results: Among the 237 patients, 76 (32.1%) were identified as having a microsatellite instability-high (MSI-H) status. No significant differences were identified in disease-free or overall survival according to the MMR status. Moreover, no association was found between the use of adjuvant chemotherapy and survival outcomes of the MSI-H group. In a multivariate survival analysis, the primary tumor location (right-sided versus left-sided, hazard ratio(HR)=0.172, p=0.003) and T-stage (HR=4.764, p=0.005) were identified as independent prognostic factors for disease-free survival. Conclusion: The present study found that the MMR status was neither prognostic nor predictive in patients with high-risk stage II CC.

AB - Background/Aim: This study evaluated the clinical significance of the mismatch repair (MMR) status and prognostic factors in patients with high-risk stage II colon cancer (CC). Materials and Methods: This was a retrospective analysis of 237 patients diagnosed with high-risk stage II CC who had test results for MMR status. Results: Among the 237 patients, 76 (32.1%) were identified as having a microsatellite instability-high (MSI-H) status. No significant differences were identified in disease-free or overall survival according to the MMR status. Moreover, no association was found between the use of adjuvant chemotherapy and survival outcomes of the MSI-H group. In a multivariate survival analysis, the primary tumor location (right-sided versus left-sided, hazard ratio(HR)=0.172, p=0.003) and T-stage (HR=4.764, p=0.005) were identified as independent prognostic factors for disease-free survival. Conclusion: The present study found that the MMR status was neither prognostic nor predictive in patients with high-risk stage II CC.

KW - Adjuvant chemotherapy

KW - High-risk features

KW - Mismatch repair

KW - Stage II colon cancer

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JO - In Vivo

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IS - 2

ER -

Clinical Implications of Mismatch Repair Status in Patients With High-risk Stage II Colon Cancer

Abstract

Keywords

UN SDGs

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