Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and oral administration in pigs

Zhi Qiang Chang, Byung Chol Oh, Jong Choon Kim, Kyu Shik Jeong, Myung Heon Lee, Hyo In Yun, Mi Hyun Hwang, Seung Chun Park

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7 Scopus citations

Abstract

The pharmacokinetics and dosage regimen of norfloxacin-glycine acetate (NFLXGA) was investigated in pigs after a single intravenous (i.v.) or oral (p.o.) administration at a dosage of 7.2 mg/kg body weight. After both i.v. and p.o. administration, plasma drug concentrations were best fitted to an open two-compartment model with a rapid distribution phase. After i.v. administration of NFLXGA, the distribution (t1/2α) and elimination half-life (t1/2β) were 0.36 ± 0.07 h and 7.42 ± 3.55 h, respectively. The volume of distribution of NFLXGA at steady state (Vd ss) was 4.66 ± 1.39 l/kg. After p.o. administration of NFLXGA, the maximal absorption concentration (Cmax) was 0.43 ± 0.06 μg/ml at 1.36 ± 0.39 h (Tmax). The mean absorption (t 1/2ka) and elimination half-life (t1/2β) of NFLXGA were 0.78 ± 0.27 h and 7.13 ± 1.41 h, respectively. The mean systemic bioavailability (F) after p.o. administration was 31.10 ± 15.16%. We suggest that the optimal dosage calculated from the pharmacokinetic parameters is 5.01 mg/kg per day i.v. or 16.12 mg/kg per day p.o.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalJournal of Veterinary Science
Volume8
Issue number4
DOIs
StatePublished - Dec 2007

Keywords

  • Norfloxacin
  • Pharmacokinetics
  • Pig

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