Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma

Jun Sik Yoon; Gyeonghwa Kim; Yu Rim Lee; Soo Young Park; Won Young Tak; Young Oh Kweon; Jung Gil Park; Hye Won Lee; Young Seok Han; Heon Tak Ha; Jae Min Chun; Se Young Jang; Keun Hur

doi:10.2217/bmm-2018-0096

Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma

Jun Sik Yoon, Gyeonghwa Kim, Yu Rim Lee, Soo Young Park, Won Young Tak, Young Oh Kweon, Jung Gil Park, Hye Won Lee, Young Seok Han, Heon Tak Ha, Jae Min Chun, Se Young Jang, Keun Hur

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Aim: Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC). Materials & methods: Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression. Results: MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues. Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage. Conclusion: Elevated miR-21 expression might represent a biomarker for HCC prognosis.

Original language	English
Pages (from-to)	1105-1114
Number of pages	10
Journal	Biomarkers in Medicine
Volume	12
Issue number	10
DOIs	https://doi.org/10.2217/bmm-2018-0096
State	Published - Oct 2018

Keywords

disease progression
hepatocellular carcinoma
microRNA-21
microRNA-31
prognosis
survival
therapeutics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/bmm-2018-0096

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@article{c735d023b3184ed8a9e3eb3fc160f13a,

title = "Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma",

abstract = "Aim: Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC). Materials & methods: Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression. Results: MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues. Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage. Conclusion: Elevated miR-21 expression might represent a biomarker for HCC prognosis.",

keywords = "disease progression, hepatocellular carcinoma, microRNA-21, microRNA-31, prognosis, survival, therapeutics",

author = "Yoon, {Jun Sik} and Gyeonghwa Kim and Lee, {Yu Rim} and Park, {Soo Young} and Tak, {Won Young} and Kweon, {Young Oh} and Park, {Jung Gil} and Lee, {Hye Won} and Han, {Young Seok} and Ha, {Heon Tak} and Chun, {Jae Min} and Jang, {Se Young} and Keun Hur",

note = "Publisher Copyright: {\textcopyright} 2018 2018 Future Medicine Ltd.",

year = "2018",

month = oct,

doi = "10.2217/bmm-2018-0096",

language = "English",

volume = "12",

pages = "1105--1114",

journal = "Biomarkers in Medicine",

issn = "1752-0363",

publisher = "Taylor and Francis Ltd.",

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}

TY - JOUR

T1 - Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma

AU - Yoon, Jun Sik

AU - Kim, Gyeonghwa

AU - Lee, Yu Rim

AU - Park, Soo Young

AU - Tak, Won Young

AU - Kweon, Young Oh

AU - Park, Jung Gil

AU - Lee, Hye Won

AU - Han, Young Seok

AU - Ha, Heon Tak

AU - Chun, Jae Min

AU - Jang, Se Young

AU - Hur, Keun

PY - 2018/10

Y1 - 2018/10

N2 - Aim: Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC). Materials & methods: Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression. Results: MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues. Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage. Conclusion: Elevated miR-21 expression might represent a biomarker for HCC prognosis.

AB - Aim: Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC). Materials & methods: Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression. Results: MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues. Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage. Conclusion: Elevated miR-21 expression might represent a biomarker for HCC prognosis.

KW - disease progression

KW - hepatocellular carcinoma

KW - microRNA-21

KW - microRNA-31

KW - prognosis

KW - survival

KW - therapeutics

UR - http://www.scopus.com/inward/record.url?scp=85054448423&partnerID=8YFLogxK

U2 - 10.2217/bmm-2018-0096

DO - 10.2217/bmm-2018-0096

M3 - Article

C2 - 30191729

AN - SCOPUS:85054448423

SN - 1752-0363

VL - 12

SP - 1105

EP - 1114

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 10

ER -

Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma

Abstract

Keywords

UN SDGs

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