Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study

Jae Ri Kim; Kee Taek Jang; Jin Young Jang; Kyungbun Lee; Jung Hoon Kim; Haeryoung Kim; Sun Whe Kim; Wooil Kwon; Dong Wook Choi; Jin Seok Heo; In Woong Han; Shin Hwang; Wan Joon Kim; Seung Mo Hong; Dong Sik Kim; Young Dong Yu; Joo Young Kim; Yang Won Nah; Hyung Woo Park; Hye Jeong Choi; Ho Seong Han; Yoo Seok Yoon; Sang Jae Park; Eun Kyung Hong; Hyung Il Seo; Do Youn Park; Koo Jeong Kang; Yu Na Kang; Hee Chul Yu; Woo Sung Moon; Chang Sup Lim; Jeong Mo Bae; Sungho Jo; Wonae Lee; Young Hun Roh; Jin Sook Jeong; Chi Young Jeong; Jong Sil Lee; In Sang Song; Kyung Hee Kim; Ho Gak Kim; Chang Ho Cho; Sun Hyung Joo; Kyu Yeoun Won; Hong Jin Kim; Joon Hyuk Choi; Chong Woo Chu; Jung Hee Lee; Il Young Park; Heejeong Lee; Seung Eun Lee; Hee Sung Kim; Hyeon Kook Lee; Min Sun Cho; Hongbeom Kim; Kang Min Han

doi:10.1016/j.hpb.2019.11.007

Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study

Jae Ri Kim, Kee Taek Jang, Jin Young Jang, Kyungbun Lee, Jung Hoon Kim, Haeryoung Kim, Sun Whe Kim, Wooil Kwon, Dong Wook Choi, Jin Seok Heo, In Woong Han, Shin Hwang, Wan Joon Kim, Seung Mo Hong, Dong Sik Kim, Young Dong Yu, Joo Young Kim, Yang Won Nah, Hyung Woo Park, Hye Jeong ChoiHo Seong Han, Yoo Seok Yoon, Sang Jae Park, Eun Kyung Hong, Hyung Il Seo, Do Youn Park, Koo Jeong Kang, Yu Na Kang, Hee Chul Yu, Woo Sung Moon, Chang Sup Lim, Jeong Mo Bae, Sungho Jo, Wonae Lee, Young Hun Roh, Jin Sook Jeong, Chi Young Jeong, Jong Sil Lee, In Sang Song, Kyung Hee Kim, Ho Gak Kim, Chang Ho Cho, Sun Hyung Joo, Kyu Yeoun Won, Hong Jin Kim, Joon Hyuk Choi, Chong Woo Chu, Jung Hee Lee, Il Young Park, Heejeong Lee, Seung Eun Lee, Hee Sung Kim, Hyeon Kook Lee, Min Sun Cho, Hongbeom Kim, Kang Min Han

Department of Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Background: IPNB is very rare disease and most previous studies on IPNB were case series with a small number due to low incidence. The aim of this study is to validate previously known clinicopathologic features of intraductal papillary neoplasm of bile duct (IPNB) based on the first largest multicenter cohort. Methods: Among 587 patients previously diagnosed with IPNB and similar diseases from each center in Korea, 387 were included in this study after central pathologic review. We also reviewed all preoperative image data. Results: Of 387 patients, 176 (45.5%) had invasive carcinoma and 21 (6.0%) lymph node metastasis. The 5-year overall survival was 80.9% for all patients, 88.8% for IPNB with mucosal dysplasia, and 70.5% for IPNB with invasive carcinoma. According to the “Jang & Kim's modified anatomical classification,” 265 (68.5%) were intrahepatic, 103 (26.6%) extrahepatic, and 16 (4.1%) diffuse type. Multivariate analysis revealed that tumor invasiveness was a unique predictor for survival analysis. (p = 0.047 [hazard ratio = 2.116, 95% confidence interval 1.010–4.433]). Conclusions: This is the first Korean multicenter study on IPNB through central pathologic and radiologic review process. Although IPNB showed good long-term prognosis, relatively aggressive features were also found in invasive carcinoma and extrahepatic/diffuse type.

Original language	English
Pages (from-to)	1139-1148
Number of pages	10
Journal	HPB
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/j.hpb.2019.11.007
State	Published - Aug 2020

Access to Document

10.1016/j.hpb.2019.11.007

Cite this

Kim, J. R., Jang, K. T., Jang, J. Y., Lee, K., Kim, J. H., Kim, H., Kim, S. W., Kwon, W., Choi, D. W., Heo, J. S., Han, I. W., Hwang, S., Kim, W. J., Hong, S. M., Kim, D. S., Yu, Y. D., Kim, J. Y., Nah, Y. W., Park, H. W., ... Han, K. M. (2020). Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study. HPB, 22(8), 1139-1148. https://doi.org/10.1016/j.hpb.2019.11.007

@article{7e6d314a7fb44ad58070058f80a8a94a,

title = "Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study",

abstract = "Background: IPNB is very rare disease and most previous studies on IPNB were case series with a small number due to low incidence. The aim of this study is to validate previously known clinicopathologic features of intraductal papillary neoplasm of bile duct (IPNB) based on the first largest multicenter cohort. Methods: Among 587 patients previously diagnosed with IPNB and similar diseases from each center in Korea, 387 were included in this study after central pathologic review. We also reviewed all preoperative image data. Results: Of 387 patients, 176 (45.5%) had invasive carcinoma and 21 (6.0%) lymph node metastasis. The 5-year overall survival was 80.9% for all patients, 88.8% for IPNB with mucosal dysplasia, and 70.5% for IPNB with invasive carcinoma. According to the “Jang & Kim's modified anatomical classification,” 265 (68.5%) were intrahepatic, 103 (26.6%) extrahepatic, and 16 (4.1%) diffuse type. Multivariate analysis revealed that tumor invasiveness was a unique predictor for survival analysis. (p = 0.047 [hazard ratio = 2.116, 95% confidence interval 1.010–4.433]). Conclusions: This is the first Korean multicenter study on IPNB through central pathologic and radiologic review process. Although IPNB showed good long-term prognosis, relatively aggressive features were also found in invasive carcinoma and extrahepatic/diffuse type.",

author = "Kim, {Jae Ri} and Jang, {Kee Taek} and Jang, {Jin Young} and Kyungbun Lee and Kim, {Jung Hoon} and Haeryoung Kim and Kim, {Sun Whe} and Wooil Kwon and Choi, {Dong Wook} and Heo, {Jin Seok} and Han, {In Woong} and Shin Hwang and Kim, {Wan Joon} and Hong, {Seung Mo} and Kim, {Dong Sik} and Yu, {Young Dong} and Kim, {Joo Young} and Nah, {Yang Won} and Park, {Hyung Woo} and Choi, {Hye Jeong} and Han, {Ho Seong} and Yoon, {Yoo Seok} and Park, {Sang Jae} and Hong, {Eun Kyung} and Seo, {Hyung Il} and Park, {Do Youn} and Kang, {Koo Jeong} and Kang, {Yu Na} and Yu, {Hee Chul} and Moon, {Woo Sung} and Lim, {Chang Sup} and Bae, {Jeong Mo} and Sungho Jo and Wonae Lee and Roh, {Young Hun} and Jeong, {Jin Sook} and Jeong, {Chi Young} and Lee, {Jong Sil} and Song, {In Sang} and Kim, {Kyung Hee} and Kim, {Ho Gak} and Cho, {Chang Ho} and Joo, {Sun Hyung} and Won, {Kyu Yeoun} and Kim, {Hong Jin} and Choi, {Joon Hyuk} and Chu, {Chong Woo} and Lee, {Jung Hee} and Park, {Il Young} and Heejeong Lee and Lee, {Seung Eun} and Kim, {Hee Sung} and Lee, {Hyeon Kook} and Cho, {Min Sun} and Hongbeom Kim and Han, {Kang Min}",

note = "Publisher Copyright: {\textcopyright} 2019 International Hepato-Pancreato-Biliary Association Inc.",

year = "2020",

month = aug,

doi = "10.1016/j.hpb.2019.11.007",

language = "English",

volume = "22",

pages = "1139--1148",

journal = "HPB",

issn = "1365-182X",

publisher = "Elsevier B.V.",

number = "8",

}

Kim, JR, Jang, KT, Jang, JY, Lee, K, Kim, JH, Kim, H, Kim, SW, Kwon, W, Choi, DW, Heo, JS, Han, IW, Hwang, S, Kim, WJ, Hong, SM, Kim, DS, Yu, YD, Kim, JY, Nah, YW, Park, HW, Choi, HJ, Han, HS, Yoon, YS, Park, SJ, Hong, EK, Seo, HI, Park, DY, Kang, KJ, Kang, YN, Yu, HC, Moon, WS, Lim, CS, Bae, JM, Jo, S, Lee, W, Roh, YH, Jeong, JS, Jeong, CY, Lee, JS, Song, IS, Kim, KH, Kim, HG, Cho, CH, Joo, SH, Won, KY, Kim, HJ, Choi, JH, Chu, CW, Lee, JH, Park, IY, Lee, H, Lee, SE, Kim, HS, Lee, HK, Cho, MS, Kim, H & Han, KM 2020, 'Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study', HPB, vol. 22, no. 8, pp. 1139-1148. https://doi.org/10.1016/j.hpb.2019.11.007

TY - JOUR

T1 - Clinicopathologic analysis of intraductal papillary neoplasm of bile duct

T2 - Korean multicenter cohort study

AU - Kim, Jae Ri

AU - Jang, Kee Taek

AU - Jang, Jin Young

AU - Lee, Kyungbun

AU - Kim, Jung Hoon

AU - Kim, Haeryoung

AU - Kim, Sun Whe

AU - Kwon, Wooil

AU - Choi, Dong Wook

AU - Heo, Jin Seok

AU - Han, In Woong

AU - Hwang, Shin

AU - Kim, Wan Joon

AU - Hong, Seung Mo

AU - Kim, Dong Sik

AU - Yu, Young Dong

AU - Kim, Joo Young

AU - Nah, Yang Won

AU - Park, Hyung Woo

AU - Choi, Hye Jeong

AU - Han, Ho Seong

AU - Yoon, Yoo Seok

AU - Park, Sang Jae

AU - Hong, Eun Kyung

AU - Seo, Hyung Il

AU - Park, Do Youn

AU - Kang, Koo Jeong

AU - Kang, Yu Na

AU - Yu, Hee Chul

AU - Moon, Woo Sung

AU - Lim, Chang Sup

AU - Bae, Jeong Mo

AU - Jo, Sungho

AU - Lee, Wonae

AU - Roh, Young Hun

AU - Jeong, Jin Sook

AU - Jeong, Chi Young

AU - Lee, Jong Sil

AU - Song, In Sang

AU - Kim, Kyung Hee

AU - Kim, Ho Gak

AU - Cho, Chang Ho

AU - Joo, Sun Hyung

AU - Won, Kyu Yeoun

AU - Kim, Hong Jin

AU - Choi, Joon Hyuk

AU - Chu, Chong Woo

AU - Lee, Jung Hee

AU - Park, Il Young

AU - Lee, Heejeong

AU - Lee, Seung Eun

AU - Kim, Hee Sung

AU - Lee, Hyeon Kook

AU - Cho, Min Sun

AU - Kim, Hongbeom

AU - Han, Kang Min

PY - 2020/8

Y1 - 2020/8

N2 - Background: IPNB is very rare disease and most previous studies on IPNB were case series with a small number due to low incidence. The aim of this study is to validate previously known clinicopathologic features of intraductal papillary neoplasm of bile duct (IPNB) based on the first largest multicenter cohort. Methods: Among 587 patients previously diagnosed with IPNB and similar diseases from each center in Korea, 387 were included in this study after central pathologic review. We also reviewed all preoperative image data. Results: Of 387 patients, 176 (45.5%) had invasive carcinoma and 21 (6.0%) lymph node metastasis. The 5-year overall survival was 80.9% for all patients, 88.8% for IPNB with mucosal dysplasia, and 70.5% for IPNB with invasive carcinoma. According to the “Jang & Kim's modified anatomical classification,” 265 (68.5%) were intrahepatic, 103 (26.6%) extrahepatic, and 16 (4.1%) diffuse type. Multivariate analysis revealed that tumor invasiveness was a unique predictor for survival analysis. (p = 0.047 [hazard ratio = 2.116, 95% confidence interval 1.010–4.433]). Conclusions: This is the first Korean multicenter study on IPNB through central pathologic and radiologic review process. Although IPNB showed good long-term prognosis, relatively aggressive features were also found in invasive carcinoma and extrahepatic/diffuse type.

AB - Background: IPNB is very rare disease and most previous studies on IPNB were case series with a small number due to low incidence. The aim of this study is to validate previously known clinicopathologic features of intraductal papillary neoplasm of bile duct (IPNB) based on the first largest multicenter cohort. Methods: Among 587 patients previously diagnosed with IPNB and similar diseases from each center in Korea, 387 were included in this study after central pathologic review. We also reviewed all preoperative image data. Results: Of 387 patients, 176 (45.5%) had invasive carcinoma and 21 (6.0%) lymph node metastasis. The 5-year overall survival was 80.9% for all patients, 88.8% for IPNB with mucosal dysplasia, and 70.5% for IPNB with invasive carcinoma. According to the “Jang & Kim's modified anatomical classification,” 265 (68.5%) were intrahepatic, 103 (26.6%) extrahepatic, and 16 (4.1%) diffuse type. Multivariate analysis revealed that tumor invasiveness was a unique predictor for survival analysis. (p = 0.047 [hazard ratio = 2.116, 95% confidence interval 1.010–4.433]). Conclusions: This is the first Korean multicenter study on IPNB through central pathologic and radiologic review process. Although IPNB showed good long-term prognosis, relatively aggressive features were also found in invasive carcinoma and extrahepatic/diffuse type.

UR - http://www.scopus.com/inward/record.url?scp=85076528453&partnerID=8YFLogxK

U2 - 10.1016/j.hpb.2019.11.007

DO - 10.1016/j.hpb.2019.11.007

M3 - Article

C2 - 31837945

AN - SCOPUS:85076528453

SN - 1365-182X

VL - 22

SP - 1139

EP - 1148

JO - HPB

JF - HPB

IS - 8

ER -

Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study

Abstract

Access to Document

Other files and links

Fingerprint

Cite this