Cobalt ion-mediated cysteine detection with a hyperbranched conjugated polyelectrolyte as a new sensing platform

Daigeun Kim; Geunseok Jang; Jongho Kim; Seongwon Seo; Won Ho Park; Taek Seung Lee

doi:10.1002/marc.201200441

Cobalt ion-mediated cysteine detection with a hyperbranched conjugated polyelectrolyte as a new sensing platform

Daigeun Kim, Geunseok Jang, Jongho Kim, Seongwon Seo, Won Ho Park, Taek Seung Lee

Department of Textile System Engineering

Chungnam National University

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A highly efficient colorimetric and fluorescence turn-off probe for the sensitive and selective detection of the biologically important amino acid, cysteine (Cys), is demonstrated using a newly synthesized water-soluble hyperbranched polymer (HP) containing sulfonic acid groups. The detection mechanism involves two steps: (i) the slight quenching of HP in the presence of Co²⁺ in advance; and (ii) the gradual quenching of the HP-Co ²⁺ complex according to the concentration of Cys due to the absorption screening effect of the formation of the Cys-Co²⁺ complex, which prevents HP from absorbing excitation energy.

Original language	English
Pages (from-to)	1510-1516
Number of pages	7
Journal	Macromolecular Rapid Communications
Volume	33
Issue number	18
DOIs	https://doi.org/10.1002/marc.201200441
State	Published - 26 Sep 2012

Keywords

conjugated polymers
cysteine sensor
fluorescence
sensors
water-soluble hyperbranched polymers

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abstract = "A highly efficient colorimetric and fluorescence turn-off probe for the sensitive and selective detection of the biologically important amino acid, cysteine (Cys), is demonstrated using a newly synthesized water-soluble hyperbranched polymer (HP) containing sulfonic acid groups. The detection mechanism involves two steps: (i) the slight quenching of HP in the presence of Co2+ in advance; and (ii) the gradual quenching of the HP-Co 2+ complex according to the concentration of Cys due to the absorption screening effect of the formation of the Cys-Co2+ complex, which prevents HP from absorbing excitation energy.",

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AU - Jang, Geunseok

AU - Kim, Jongho

AU - Seo, Seongwon

AU - Park, Won Ho

AU - Lee, Taek Seung

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AB - A highly efficient colorimetric and fluorescence turn-off probe for the sensitive and selective detection of the biologically important amino acid, cysteine (Cys), is demonstrated using a newly synthesized water-soluble hyperbranched polymer (HP) containing sulfonic acid groups. The detection mechanism involves two steps: (i) the slight quenching of HP in the presence of Co2+ in advance; and (ii) the gradual quenching of the HP-Co 2+ complex according to the concentration of Cys due to the absorption screening effect of the formation of the Cys-Co2+ complex, which prevents HP from absorbing excitation energy.

KW - conjugated polymers

KW - cysteine sensor

KW - fluorescence

KW - sensors

KW - water-soluble hyperbranched polymers

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Cobalt ion-mediated cysteine detection with a hyperbranched conjugated polyelectrolyte as a new sensing platform

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