Cognitive effects of low-dose topiramate monotherapy in epilepsy patients: A 1-year follow-up

Ho Won Lee; Doo Kyo Jung; Chung Kyu Suh; Soon Hak Kwon; Sung Pa Park

doi:10.1016/j.yebeh.2006.03.006

Cognitive effects of low-dose topiramate monotherapy in epilepsy patients: A 1-year follow-up

Ho Won Lee
, Doo Kyo Jung
, Chung Kyu Suh
, Soon Hak Kwon
, Sung Pa Park

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

The present study was conducted to evaluate the long-term effects of low-dose topiramate (TPM) monotherapy on the cognitive function of epilepsy patients. Forty-seven epilepsy patients received TPM, with target doses of 50, 75, and 100 mg/day. Cognitive tests were performed twice, at baseline and 1 year after starting medication. Thirty-six patients completed the follow-up neuropsychological tests. After a year of treatment, 16 patients (44%) complained of cognitive problems. Although it improved seizure frequency and EEG abnormalities, TPM had significantly negative effects on the digit span and verbal fluency tests. These cognitive effects were dose-related and significantly improved after withdrawal from TPM and substitution with older antiepileptic drugs. In conclusion, even at a low dose, TPM has long-term, negative effects on working memory and verbal fluency.

Original language	English
Pages (from-to)	736-741
Number of pages	6
Journal	Epilepsy and Behavior
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/j.yebeh.2006.03.006
State	Published - Jun 2006

Keywords

Adverse effects
Cognition
Epilepsy
Topiramate

Access to Document

10.1016/j.yebeh.2006.03.006

Cite this

@article{8ca32aa08d9a459199476deda4bbfeb5,

title = "Cognitive effects of low-dose topiramate monotherapy in epilepsy patients: A 1-year follow-up",

abstract = "The present study was conducted to evaluate the long-term effects of low-dose topiramate (TPM) monotherapy on the cognitive function of epilepsy patients. Forty-seven epilepsy patients received TPM, with target doses of 50, 75, and 100 mg/day. Cognitive tests were performed twice, at baseline and 1 year after starting medication. Thirty-six patients completed the follow-up neuropsychological tests. After a year of treatment, 16 patients (44\%) complained of cognitive problems. Although it improved seizure frequency and EEG abnormalities, TPM had significantly negative effects on the digit span and verbal fluency tests. These cognitive effects were dose-related and significantly improved after withdrawal from TPM and substitution with older antiepileptic drugs. In conclusion, even at a low dose, TPM has long-term, negative effects on working memory and verbal fluency.",

keywords = "Adverse effects, Cognition, Epilepsy, Topiramate",

author = "Lee, \{Ho Won\} and Jung, \{Doo Kyo\} and Suh, \{Chung Kyu\} and Kwon, \{Soon Hak\} and Park, \{Sung Pa\}",

year = "2006",

month = jun,

doi = "10.1016/j.yebeh.2006.03.006",

language = "English",

volume = "8",

pages = "736--741",

journal = "Epilepsy and Behavior",

issn = "1525-5050",

publisher = "Academic Press Inc.",

number = "4",

}

TY - JOUR

T1 - Cognitive effects of low-dose topiramate monotherapy in epilepsy patients

T2 - A 1-year follow-up

AU - Lee, Ho Won

AU - Jung, Doo Kyo

AU - Suh, Chung Kyu

AU - Kwon, Soon Hak

AU - Park, Sung Pa

PY - 2006/6

Y1 - 2006/6

N2 - The present study was conducted to evaluate the long-term effects of low-dose topiramate (TPM) monotherapy on the cognitive function of epilepsy patients. Forty-seven epilepsy patients received TPM, with target doses of 50, 75, and 100 mg/day. Cognitive tests were performed twice, at baseline and 1 year after starting medication. Thirty-six patients completed the follow-up neuropsychological tests. After a year of treatment, 16 patients (44%) complained of cognitive problems. Although it improved seizure frequency and EEG abnormalities, TPM had significantly negative effects on the digit span and verbal fluency tests. These cognitive effects were dose-related and significantly improved after withdrawal from TPM and substitution with older antiepileptic drugs. In conclusion, even at a low dose, TPM has long-term, negative effects on working memory and verbal fluency.

AB - The present study was conducted to evaluate the long-term effects of low-dose topiramate (TPM) monotherapy on the cognitive function of epilepsy patients. Forty-seven epilepsy patients received TPM, with target doses of 50, 75, and 100 mg/day. Cognitive tests were performed twice, at baseline and 1 year after starting medication. Thirty-six patients completed the follow-up neuropsychological tests. After a year of treatment, 16 patients (44%) complained of cognitive problems. Although it improved seizure frequency and EEG abnormalities, TPM had significantly negative effects on the digit span and verbal fluency tests. These cognitive effects were dose-related and significantly improved after withdrawal from TPM and substitution with older antiepileptic drugs. In conclusion, even at a low dose, TPM has long-term, negative effects on working memory and verbal fluency.

KW - Adverse effects

KW - Cognition

KW - Epilepsy

KW - Topiramate

UR - https://www.scopus.com/pages/publications/33646511090

U2 - 10.1016/j.yebeh.2006.03.006

DO - 10.1016/j.yebeh.2006.03.006

M3 - Article

C2 - 16647301

AN - SCOPUS:33646511090

SN - 1525-5050

VL - 8

SP - 736

EP - 741

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

IS - 4

ER -

Cognitive effects of low-dose topiramate monotherapy in epilepsy patients: A 1-year follow-up

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this