Colloidal properties of surface coated colloidal silica nanoparticles in aqueous and physiological solutions

Kyoung Min Kim, Hyoung Mi Kim, Moon Hyung Choi, Jong Kwon Lee, Jayoung Jeong, Min Ho Lee, Yoon Suk Kim, Seung Min Paek, Jae Min Oh

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Silica nanomaterials have attracted considerable interest as advanced materials in industrial and bio-medical research. This study examined the colloidal properties of silica (SiO2) nanomaterials such as particle size, zeta potential and hydrodynamic size under various aqueous conditions, such as deionized water (DI), phosphate buffered saline (PBS) and human plasma. To examine the effects of size and surface chemistry on the colloidal behavior, colloidal silicas with two different sizes (20 and 100 nm) were selected and their surface was modified with L-arginine under controlled pH conditions. Surface modification did not affect the particle size and morphology in aqueous system but altered the surface charge. All the silica samples showed clear Tyndall effect in DI, PBS, and human plasma under greenish laser irradiation, suggesting that their colloidal properties were well preserved in physiological solutions. We also evaluated the fluorescence quenching of plasma protein upon silica treatment and showed that silica nanomaterials do not induce serious protein aggregation.

Original languageEnglish
Pages (from-to)1573-1581
Number of pages9
JournalScience of Advanced Materials
Volume6
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • Biological behavior
  • Colloid
  • L-Arginine
  • Nanomaterials
  • Silica

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