Comparative Pharmacokinetic Profiles of Two Norfloxacin Formulations after Oral Administration in Rabbits

Seung Chun Park; Hyo In Yun; Tae Kwang Oh

doi:10.1292/jvms.60.661

Comparative Pharmacokinetic Profiles of Two Norfloxacin Formulations after Oral Administration in Rabbits

Seung Chun Park, Hyo In Yun, Tae Kwang Oh

Department of Veterinary Medicine

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

The pharmacokinetics and tissue distribution of two norfloxacin (NFLX) formulations, norfloxacin-glycine acetate (NFLXGA) and norfloxacin nicotinate (NFLXN). were compared after single oral administration with a dose of 5 mg equivalent NFLX base/kg of body weight in twenty rabbits. The pharmacokinetic characteristics of all formulations were fitted by a two-compartment open model. The elimination half-life (T_1,2β) of NFLX (3.37 ± 1.37 hr) was not significant as compared with those of NFLXN (3.61 ± 0.65 hr) and NFLXGA (3.93 ± 1.54 hr). The absolute bioavailability (F) of NFLX, NFLXN and NFLXGA was calculated as 29%, 45% and 40%. In addition, tissue distribution of NFLXN and NFLXGA did not show any differences of NFLX concentrations in liver, kidney, serum and muscle. From the present results, it could be suggested that NFLXN and NFLXGA are considered to be bioequivalent when they use oral medication for rabbits.

Original language	English
Pages (from-to)	661-663
Number of pages	3
Journal	Journal of Veterinary Medical Science
Volume	60
Issue number	5
DOIs	https://doi.org/10.1292/jvms.60.661
State	Published - May 1998

Keywords

Bioavailability
Norfloxacin
Rabbit

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title = "Comparative Pharmacokinetic Profiles of Two Norfloxacin Formulations after Oral Administration in Rabbits",

abstract = "The pharmacokinetics and tissue distribution of two norfloxacin (NFLX) formulations, norfloxacin-glycine acetate (NFLXGA) and norfloxacin nicotinate (NFLXN). were compared after single oral administration with a dose of 5 mg equivalent NFLX base/kg of body weight in twenty rabbits. The pharmacokinetic characteristics of all formulations were fitted by a two-compartment open model. The elimination half-life (T1,2β) of NFLX (3.37 ± 1.37 hr) was not significant as compared with those of NFLXN (3.61 ± 0.65 hr) and NFLXGA (3.93 ± 1.54 hr). The absolute bioavailability (F) of NFLX, NFLXN and NFLXGA was calculated as 29%, 45% and 40%. In addition, tissue distribution of NFLXN and NFLXGA did not show any differences of NFLX concentrations in liver, kidney, serum and muscle. From the present results, it could be suggested that NFLXN and NFLXGA are considered to be bioequivalent when they use oral medication for rabbits.",

keywords = "Bioavailability, Norfloxacin, Rabbit",

author = "Park, {Seung Chun} and Yun, {Hyo In} and Oh, {Tae Kwang}",

year = "1998",

month = may,

doi = "10.1292/jvms.60.661",

language = "English",

volume = "60",

pages = "661--663",

journal = "Journal of Veterinary Medical Science",

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publisher = "Japanese Society of Veterinary Science",

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T1 - Comparative Pharmacokinetic Profiles of Two Norfloxacin Formulations after Oral Administration in Rabbits

AU - Park, Seung Chun

AU - Yun, Hyo In

AU - Oh, Tae Kwang

PY - 1998/5

Y1 - 1998/5

N2 - The pharmacokinetics and tissue distribution of two norfloxacin (NFLX) formulations, norfloxacin-glycine acetate (NFLXGA) and norfloxacin nicotinate (NFLXN). were compared after single oral administration with a dose of 5 mg equivalent NFLX base/kg of body weight in twenty rabbits. The pharmacokinetic characteristics of all formulations were fitted by a two-compartment open model. The elimination half-life (T1,2β) of NFLX (3.37 ± 1.37 hr) was not significant as compared with those of NFLXN (3.61 ± 0.65 hr) and NFLXGA (3.93 ± 1.54 hr). The absolute bioavailability (F) of NFLX, NFLXN and NFLXGA was calculated as 29%, 45% and 40%. In addition, tissue distribution of NFLXN and NFLXGA did not show any differences of NFLX concentrations in liver, kidney, serum and muscle. From the present results, it could be suggested that NFLXN and NFLXGA are considered to be bioequivalent when they use oral medication for rabbits.

AB - The pharmacokinetics and tissue distribution of two norfloxacin (NFLX) formulations, norfloxacin-glycine acetate (NFLXGA) and norfloxacin nicotinate (NFLXN). were compared after single oral administration with a dose of 5 mg equivalent NFLX base/kg of body weight in twenty rabbits. The pharmacokinetic characteristics of all formulations were fitted by a two-compartment open model. The elimination half-life (T1,2β) of NFLX (3.37 ± 1.37 hr) was not significant as compared with those of NFLXN (3.61 ± 0.65 hr) and NFLXGA (3.93 ± 1.54 hr). The absolute bioavailability (F) of NFLX, NFLXN and NFLXGA was calculated as 29%, 45% and 40%. In addition, tissue distribution of NFLXN and NFLXGA did not show any differences of NFLX concentrations in liver, kidney, serum and muscle. From the present results, it could be suggested that NFLXN and NFLXGA are considered to be bioequivalent when they use oral medication for rabbits.

KW - Bioavailability

KW - Norfloxacin

KW - Rabbit

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M3 - Review article

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JO - Journal of Veterinary Medical Science

JF - Journal of Veterinary Medical Science

IS - 5

ER -

Comparative Pharmacokinetic Profiles of Two Norfloxacin Formulations after Oral Administration in Rabbits

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Keywords

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