Comparison of clinical features and oncologic outcomes between familial non-hereditary and hereditary breast cancer in Korean female patients

Chan Sub Park, Ho Yong Park, Jin Hyang Jung, Wan Wook Kim, Yee Soo Chae, Soo Jung Lee, Ji Young Park, Jee Young Park, Jeeyeon Lee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: The authors compared the clinical features between familial (non-hereditary) and hereditary breast cancer. And we also analyzed their oncologic outcomes to establish appropriate surveillance protocol for familial (non-hereditary) and hereditary breast cancer. Methods: Among 232 patients with breast cancer who were performed BRCA gene evaluation, twenty-eight patients were diagnosed as hereditary breast cancer with BRCA gene mutation and one-hundred and seventy-six patients were familial (non-hereditary) breast cancer. The clinical characteristics and oncologic outcomes were compared between two groups. Results: While the incidence of multifocality was higher in familial (non-hereditary) breast cancer group (p < 0.001), the bilaterality was higher in hereditary breast cancer group (p < 0.001). And the rate of pathologic complete remission was also significantly higher in hereditary breast cancer group (p = 0.030). The characteristics of tumor were different between familial (non-hereditary) breast cancer and hereditary breast cancer. The oncologic outcome was better in familial (non-hereditary) breast cancer group than hereditary breast cancer group except death. Conclusion: The clinical characteristics of familial (non-hereditary) breast cancer were different from those of hereditary breast cancer but similar to those of sporadic breast cancer. The prognosis of the familial (non-hereditary) breast cancer was significantly better than hereditary breast cancer.

Original languageEnglish
Pages (from-to)996-1001
Number of pages6
JournalAsian Journal of Surgery
Volume43
Issue number10
DOIs
StatePublished - Oct 2020

Keywords

  • BRCA
  • Breast
  • Carcinoma
  • Familial
  • Hereditary

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