Comparison of Rapid Diagnostic Tests for the Detection of Plasmodium vivax Malaria in South Korea

Jung Yeon Kim; So Young Ji; Youn Kyoung Goo; Byoung Kuk Na; Hyo Joo Pyo; Han Na Lee; Juyoung Lee; Nam Hee Kim; Lorenz von Seidlein; Qin Cheng; Shin Hyung Cho; Won Ja Lee

doi:10.1371/journal.pone.0064353

Comparison of Rapid Diagnostic Tests for the Detection of Plasmodium vivax Malaria in South Korea

Jung Yeon Kim, So Young Ji, Youn Kyoung Goo, Byoung Kuk Na, Hyo Joo Pyo, Han Na Lee, Juyoung Lee, Nam Hee Kim, Lorenz von Seidlein, Qin Cheng, Shin Hyung Cho, Won Ja Lee

Department of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

South Korea is one of many countries with endemic Plasmodium vivax malaria. Here we report the evaluation of four rapid diagnostic tests (RDTs) for diagnosis of this disease. A total of 253 subjects were enrolled in the study. The sensitivities, specificities and agreement frequencies were estimated by comparing the four RDTs against the standard of nested-PCR and microscopic examination. The CareStart^TM and SD Bioline had higher test sensitivities (99.4 and 98.8%, respectively) compared with the NanoSign and Asan Easy tests (93.0 and 94.7%, respectively). The CareStart^TM and SD Bioline tests could detect P. vivax in samples with parasite densities <150/μl, which was a slightly better performance than the other two RDTs. The quantitative accuracy of the four RDTs was also estimated by comparing results with P. vivax counts from blood samples. Lower test price would result in increased use of these RDTs in the field. The results of this study contribute valuable information that will aid in the selection of a diagnostic method for the detection of malaria.

Original language	English
Article number	e64353
Journal	PLoS ONE
Volume	8
Issue number	5
DOIs	https://doi.org/10.1371/journal.pone.0064353
State	Published - 7 May 2013

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title = "Comparison of Rapid Diagnostic Tests for the Detection of Plasmodium vivax Malaria in South Korea",

abstract = "South Korea is one of many countries with endemic Plasmodium vivax malaria. Here we report the evaluation of four rapid diagnostic tests (RDTs) for diagnosis of this disease. A total of 253 subjects were enrolled in the study. The sensitivities, specificities and agreement frequencies were estimated by comparing the four RDTs against the standard of nested-PCR and microscopic examination. The CareStartTM and SD Bioline had higher test sensitivities (99.4 and 98.8%, respectively) compared with the NanoSign and Asan Easy tests (93.0 and 94.7%, respectively). The CareStartTM and SD Bioline tests could detect P. vivax in samples with parasite densities <150/μl, which was a slightly better performance than the other two RDTs. The quantitative accuracy of the four RDTs was also estimated by comparing results with P. vivax counts from blood samples. Lower test price would result in increased use of these RDTs in the field. The results of this study contribute valuable information that will aid in the selection of a diagnostic method for the detection of malaria.",

author = "Kim, {Jung Yeon} and Ji, {So Young} and Goo, {Youn Kyoung} and Na, {Byoung Kuk} and Pyo, {Hyo Joo} and Lee, {Han Na} and Juyoung Lee and Kim, {Nam Hee} and {von Seidlein}, Lorenz and Qin Cheng and Cho, {Shin Hyung} and Lee, {Won Ja}",

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AU - Pyo, Hyo Joo

AU - Lee, Han Na

AU - Lee, Juyoung

AU - Kim, Nam Hee

AU - von Seidlein, Lorenz

AU - Cheng, Qin

AU - Cho, Shin Hyung

AU - Lee, Won Ja

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N2 - South Korea is one of many countries with endemic Plasmodium vivax malaria. Here we report the evaluation of four rapid diagnostic tests (RDTs) for diagnosis of this disease. A total of 253 subjects were enrolled in the study. The sensitivities, specificities and agreement frequencies were estimated by comparing the four RDTs against the standard of nested-PCR and microscopic examination. The CareStartTM and SD Bioline had higher test sensitivities (99.4 and 98.8%, respectively) compared with the NanoSign and Asan Easy tests (93.0 and 94.7%, respectively). The CareStartTM and SD Bioline tests could detect P. vivax in samples with parasite densities <150/μl, which was a slightly better performance than the other two RDTs. The quantitative accuracy of the four RDTs was also estimated by comparing results with P. vivax counts from blood samples. Lower test price would result in increased use of these RDTs in the field. The results of this study contribute valuable information that will aid in the selection of a diagnostic method for the detection of malaria.

AB - South Korea is one of many countries with endemic Plasmodium vivax malaria. Here we report the evaluation of four rapid diagnostic tests (RDTs) for diagnosis of this disease. A total of 253 subjects were enrolled in the study. The sensitivities, specificities and agreement frequencies were estimated by comparing the four RDTs against the standard of nested-PCR and microscopic examination. The CareStartTM and SD Bioline had higher test sensitivities (99.4 and 98.8%, respectively) compared with the NanoSign and Asan Easy tests (93.0 and 94.7%, respectively). The CareStartTM and SD Bioline tests could detect P. vivax in samples with parasite densities <150/μl, which was a slightly better performance than the other two RDTs. The quantitative accuracy of the four RDTs was also estimated by comparing results with P. vivax counts from blood samples. Lower test price would result in increased use of these RDTs in the field. The results of this study contribute valuable information that will aid in the selection of a diagnostic method for the detection of malaria.

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Comparison of Rapid Diagnostic Tests for the Detection of Plasmodium vivax Malaria in South Korea

Abstract

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