Comparisons of phenolic compounds and antioxidant activities during different growth stages in Artemisia gmelinii Weber ex Stechm with UPLC-QTOF/MS based on a metabolomics approach

Seon Min Oh; Doo Young Kim; Su Yeon Lee; Ha Eun Song; In Seon Kim; Woo Duck Seo; Jeong Hoon Lee; Sei Ryang Oh; Dae Young Lee; Hyung Won Ryu

doi:10.1016/j.indcrop.2023.116999

Comparisons of phenolic compounds and antioxidant activities during different growth stages in Artemisia gmelinii Weber ex Stechm with UPLC-QTOF/MS based on a metabolomics approach

Seon Min Oh, Doo Young Kim, Su Yeon Lee, Ha Eun Song, In Seon Kim, Woo Duck Seo, Jeong Hoon Lee, Sei Ryang Oh, Dae Young Lee, Hyung Won Ryu

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Metabolomics approaches are becoming popular for a rational and efficient approach to standardize research including optimal harvest time determination to improve the values of plant raw materials. In this study, multivariate statistical analysis of metabolites from Artemisia gmelinii Weber ex Stechm (AG) by growth stage according to harvest time (from June to October) was performed by ultra-performance liquid chromatography (UPLC) coupled with quadrupole time of flight mass spectrometry (Q-TOF/MS). Secondary metabolite analysis through PCA provided clearly distinguishable patterns and qualitative R²X values (93.7%) for the corresponding markers. From the OPLS-DA, ten phenolic compounds were found as biomarkers exhibiting distinct patterns according to the harvesting periods (June-Aug: five phenolic acids, Aug-Oct: five flavonoids), and the contents of these phenolic compounds, well-known antioxidants, were increased according to the growth period (Oct > Aug > June). In conclusion, the harvesting time of plant raw materials could be sufficiently determined through the metabolomics study of secondary metabolites.

Original language	English
Article number	116999
Journal	Industrial Crops and Products
Volume	202
DOIs	https://doi.org/10.1016/j.indcrop.2023.116999
State	Published - 15 Oct 2023

Keywords

Antioxidant
Artemisia gmelinii Weber ex Stechm
Harvest period
Multivariate statistical analysis
Phytochemicals

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10.1016/j.indcrop.2023.116999

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Oh, S. M., Kim, D. Y., Lee, S. Y., Song, H. E., Kim, I. S., Seo, W. D., Lee, J. H., Oh, S. R., Lee, D. Y., & Ryu, H. W. (2023). Comparisons of phenolic compounds and antioxidant activities during different growth stages in Artemisia gmelinii Weber ex Stechm with UPLC-QTOF/MS based on a metabolomics approach. Industrial Crops and Products, 202, Article 116999. https://doi.org/10.1016/j.indcrop.2023.116999

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title = "Comparisons of phenolic compounds and antioxidant activities during different growth stages in Artemisia gmelinii Weber ex Stechm with UPLC-QTOF/MS based on a metabolomics approach",

abstract = "Metabolomics approaches are becoming popular for a rational and efficient approach to standardize research including optimal harvest time determination to improve the values of plant raw materials. In this study, multivariate statistical analysis of metabolites from Artemisia gmelinii Weber ex Stechm (AG) by growth stage according to harvest time (from June to October) was performed by ultra-performance liquid chromatography (UPLC) coupled with quadrupole time of flight mass spectrometry (Q-TOF/MS). Secondary metabolite analysis through PCA provided clearly distinguishable patterns and qualitative R2X values (93.7%) for the corresponding markers. From the OPLS-DA, ten phenolic compounds were found as biomarkers exhibiting distinct patterns according to the harvesting periods (June-Aug: five phenolic acids, Aug-Oct: five flavonoids), and the contents of these phenolic compounds, well-known antioxidants, were increased according to the growth period (Oct > Aug > June). In conclusion, the harvesting time of plant raw materials could be sufficiently determined through the metabolomics study of secondary metabolites.",

keywords = "Antioxidant, Artemisia gmelinii Weber ex Stechm, Harvest period, Multivariate statistical analysis, Phytochemicals",

author = "Oh, {Seon Min} and Kim, {Doo Young} and Lee, {Su Yeon} and Song, {Ha Eun} and Kim, {In Seon} and Seo, {Woo Duck} and Lee, {Jeong Hoon} and Oh, {Sei Ryang} and Lee, {Dae Young} and Ryu, {Hyung Won}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

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day = "15",

doi = "10.1016/j.indcrop.2023.116999",

language = "English",

volume = "202",

journal = "Industrial Crops and Products",

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publisher = "Elsevier B.V.",

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Oh, SM, Kim, DY, Lee, SY, Song, HE, Kim, IS, Seo, WD, Lee, JH, Oh, SR, Lee, DY & Ryu, HW 2023, 'Comparisons of phenolic compounds and antioxidant activities during different growth stages in Artemisia gmelinii Weber ex Stechm with UPLC-QTOF/MS based on a metabolomics approach', Industrial Crops and Products, vol. 202, 116999. https://doi.org/10.1016/j.indcrop.2023.116999

TY - JOUR

T1 - Comparisons of phenolic compounds and antioxidant activities during different growth stages in Artemisia gmelinii Weber ex Stechm with UPLC-QTOF/MS based on a metabolomics approach

AU - Oh, Seon Min

AU - Kim, Doo Young

AU - Lee, Su Yeon

AU - Song, Ha Eun

AU - Kim, In Seon

AU - Seo, Woo Duck

AU - Lee, Jeong Hoon

AU - Oh, Sei Ryang

AU - Lee, Dae Young

AU - Ryu, Hyung Won

PY - 2023/10/15

Y1 - 2023/10/15

N2 - Metabolomics approaches are becoming popular for a rational and efficient approach to standardize research including optimal harvest time determination to improve the values of plant raw materials. In this study, multivariate statistical analysis of metabolites from Artemisia gmelinii Weber ex Stechm (AG) by growth stage according to harvest time (from June to October) was performed by ultra-performance liquid chromatography (UPLC) coupled with quadrupole time of flight mass spectrometry (Q-TOF/MS). Secondary metabolite analysis through PCA provided clearly distinguishable patterns and qualitative R2X values (93.7%) for the corresponding markers. From the OPLS-DA, ten phenolic compounds were found as biomarkers exhibiting distinct patterns according to the harvesting periods (June-Aug: five phenolic acids, Aug-Oct: five flavonoids), and the contents of these phenolic compounds, well-known antioxidants, were increased according to the growth period (Oct > Aug > June). In conclusion, the harvesting time of plant raw materials could be sufficiently determined through the metabolomics study of secondary metabolites.

AB - Metabolomics approaches are becoming popular for a rational and efficient approach to standardize research including optimal harvest time determination to improve the values of plant raw materials. In this study, multivariate statistical analysis of metabolites from Artemisia gmelinii Weber ex Stechm (AG) by growth stage according to harvest time (from June to October) was performed by ultra-performance liquid chromatography (UPLC) coupled with quadrupole time of flight mass spectrometry (Q-TOF/MS). Secondary metabolite analysis through PCA provided clearly distinguishable patterns and qualitative R2X values (93.7%) for the corresponding markers. From the OPLS-DA, ten phenolic compounds were found as biomarkers exhibiting distinct patterns according to the harvesting periods (June-Aug: five phenolic acids, Aug-Oct: five flavonoids), and the contents of these phenolic compounds, well-known antioxidants, were increased according to the growth period (Oct > Aug > June). In conclusion, the harvesting time of plant raw materials could be sufficiently determined through the metabolomics study of secondary metabolites.

KW - Antioxidant

KW - Artemisia gmelinii Weber ex Stechm

KW - Harvest period

KW - Multivariate statistical analysis

KW - Phytochemicals

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DO - 10.1016/j.indcrop.2023.116999

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AN - SCOPUS:85161600357

SN - 0926-6690

VL - 202

JO - Industrial Crops and Products

JF - Industrial Crops and Products

M1 - 116999

ER -

Comparisons of phenolic compounds and antioxidant activities during different growth stages in Artemisia gmelinii Weber ex Stechm with UPLC-QTOF/MS based on a metabolomics approach

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Keywords

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