Complexation of the non-steroidal anti-inflammatory drug loxoprofen with modified and unmodified β-cyclodextrins

The inclusion complex of the anti-inflammatory drug, loxoprofen, with β-cyclodextrin-(CD), sulfated β-CD, and glycerol ether β-CD was studied by UV-VIS absorption and ¹H-NMR spectroscopy in solution. The inclusion complex of loxoprofen with β-CDs was prepared by freeze-drying, and then characterized in the solid state by thermal analysis, X-ray diffraction, FT-IR and FT-Raman spectroscopy, and scanning electron microscopy (SEM). Furthermore, a physical mixture of loxoprofen/β-CD (1/1, mol-%) in the solid state was also characterized. The solubility of the loxoprofen increased on addition of β-CDs. The solubility enhancement of the loxoprofen with β-CDs is in the following order: glycerol ether β-CD > sulfated β-CD > β-CD.