Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity

Hoang Viet Dung; To Dao Cuong; Nguyen Minh Chinh; Do Quyen; Jeong Ah Kim; Jeong Su Byeon; Mi Hee Woo; Jae Sui Choi; Byung Sun Min

doi:10.1007/s12272-014-0432-3

Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity

Hoang Viet Dung, To Dao Cuong, Nguyen Minh Chinh, Do Quyen, Jeong Ah Kim, Jeong Su Byeon, Mi Hee Woo, Jae Sui Choi, Byung Sun Min

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC₅₀ values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC₅₀ value of 19.25 μM.

Original language	English
Pages (from-to)	677-682
Number of pages	6
Journal	Archives of Pharmacal Research
Volume	38
Issue number	5
DOIs	https://doi.org/10.1007/s12272-014-0432-3
State	Published - 1 May 2015

Keywords

AChE
Alzheimer's disease
BChE
Piper bavinum
Piperaceae

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10.1007/s12272-014-0432-3

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title = "Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity",

abstract = "A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.",

keywords = "AChE, Alzheimer's disease, BChE, Piper bavinum, Piperaceae",

author = "Dung, {Hoang Viet} and Cuong, {To Dao} and Chinh, {Nguyen Minh} and Do Quyen and Kim, {Jeong Ah} and Byeon, {Jeong Su} and Woo, {Mi Hee} and Choi, {Jae Sui} and Min, {Byung Sun}",

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doi = "10.1007/s12272-014-0432-3",

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AU - Dung, Hoang Viet

AU - Cuong, To Dao

AU - Chinh, Nguyen Minh

AU - Quyen, Do

AU - Kim, Jeong Ah

AU - Byeon, Jeong Su

AU - Woo, Mi Hee

AU - Choi, Jae Sui

AU - Min, Byung Sun

PY - 2015/5/1

Y1 - 2015/5/1

N2 - A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.

AB - A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.

KW - AChE

KW - Alzheimer's disease

KW - BChE

KW - Piper bavinum

KW - Piperaceae

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SN - 0253-6269

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SP - 677

EP - 682

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 5

ER -

Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity

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Keywords

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