Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity

Hoang Viet Dung; To Dao Cuong; Nguyen Minh Chinh; Do Quyen; Jeong Ah Kim; Jeong Su Byeon; Mi Hee Woo; Jae Sui Choi; Byung Sun Min

doi:10.1007/s12272-014-0432-3

Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity

Hoang Viet Dung
, To Dao Cuong
, Nguyen Minh Chinh
, Do Quyen
, Jeong Ah Kim
, Jeong Su Byeon
, Mi Hee Woo
, Jae Sui Choi
, Byung Sun Min

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC₅₀ values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC₅₀ value of 19.25 μM.

Original language	English
Pages (from-to)	677-682
Number of pages	6
Journal	Archives of Pharmacal Research
Volume	38
Issue number	5
DOIs	https://doi.org/10.1007/s12272-014-0432-3
State	Published - 1 May 2015

Keywords

AChE
Alzheimer's disease
BChE
Piper bavinum
Piperaceae

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10.1007/s12272-014-0432-3

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title = "Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity",

abstract = "A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.",

keywords = "AChE, Alzheimer's disease, BChE, Piper bavinum, Piperaceae",

author = "Dung, \{Hoang Viet\} and Cuong, \{To Dao\} and Chinh, \{Nguyen Minh\} and Do Quyen and Kim, \{Jeong Ah\} and Byeon, \{Jeong Su\} and Woo, \{Mi Hee\} and Choi, \{Jae Sui\} and Min, \{Byung Sun\}",

note = "Publisher Copyright: {\textcopyright} 2014 The Pharmaceutical Society of Korea.",

year = "2015",

month = may,

day = "1",

doi = "10.1007/s12272-014-0432-3",

language = "English",

volume = "38",

pages = "677--682",

journal = "Archives of Pharmacal Research",

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TY - JOUR

T1 - Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity

AU - Dung, Hoang Viet

AU - Cuong, To Dao

AU - Chinh, Nguyen Minh

AU - Quyen, Do

AU - Kim, Jeong Ah

AU - Byeon, Jeong Su

AU - Woo, Mi Hee

AU - Choi, Jae Sui

AU - Min, Byung Sun

PY - 2015/5/1

Y1 - 2015/5/1

N2 - A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.

AB - A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.

KW - AChE

KW - Alzheimer's disease

KW - BChE

KW - Piper bavinum

KW - Piperaceae

UR - https://www.scopus.com/pages/publications/84939874269

U2 - 10.1007/s12272-014-0432-3

DO - 10.1007/s12272-014-0432-3

M3 - Article

C2 - 25005067

AN - SCOPUS:84939874269

SN - 0253-6269

VL - 38

SP - 677

EP - 682

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 5

ER -

Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity

Abstract

Keywords

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