Consensus Definition of Blood Samples from the Subcategorized Normal Controls in the Korea Biobank Network

Ji Eun Han, Min Kyu Park, Ju Hyun Jin, Jung Ah Lee, Gyeongsin Park, Jong Sook Park, Han Ik Bae, Seok Joong Yun, An Na Seo, Man Hoon Han, Hyoungnam Lee, Jae Pil Jeon, Ji In Yu, Soon Sun Kim, Jae Youn Cheong

Research output: Contribution to journalArticlepeer-review

Abstract

A control group is defined as a group of people used for comparison. Depending on the type of study, it can be a group of healthy people or a group not exposed to risk factors. It is important to allow researchers to select the appropriate control participants. The Korea Biobank Project-sponsored biobanks are affiliated with the Korea Biobank Network (KBN), for which the National Biobank of Korea plays a central coordinating role among KBN biobanks. KBN organized several working groups to address new challenges and needs in biobanking. The “Normal Healthy Control Working Group” developed standardized criteria for three defined control groups, namely, normal, normal-plus, and disease-specific controls. Based on the consensus on the definition of a normal control, we applied the criteria for normal control participants to retrospective data. The main reason for exclusion from the “Normal-plus” group was blood test results beyond 5% of the reference range, including hypercholesterolemia. Subclassification of samples of normal controls by detailed criteria will help researchers select optimal normal controls for their studies.

Original languageEnglish
Article number3080
JournalJournal of Clinical Medicine
Volume12
Issue number9
DOIs
StatePublished - May 2023

Keywords

  • biobank
  • biospecimen
  • control definition
  • healthy control
  • Korea Biobank Network
  • normal control

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