Construction of Binuclear Benzimidazole-Fused Quinazolinones and Pyrimidinones Using Aryl Isocyanates as Building Blocks by Transition-Metal-Free C(sp2)-N Coupling

Pham Duy Quang Dao; Chan Sik Cho

doi:10.1021/acs.joc.0c02067

Construction of Binuclear Benzimidazole-Fused Quinazolinones and Pyrimidinones Using Aryl Isocyanates as Building Blocks by Transition-Metal-Free C(sp²)-N Coupling

Pham Duy Quang Dao
, Chan Sik Cho

Department of Applied Chemistry

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A class of binuclear N-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with aryl isocyanates as building blocks in the presence of a base under microwave irradiation. A nucleophilic addition followed by an unprecedented transition-metal-free C(sp2)-N coupling is proposed as a reaction pathway of this green process.

Original language	English
Pages (from-to)	13354-13362
Number of pages	9
Journal	Journal of Organic Chemistry
Volume	85
Issue number	20
DOIs	https://doi.org/10.1021/acs.joc.0c02067
State	Published - 16 Oct 2020

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title = "Construction of Binuclear Benzimidazole-Fused Quinazolinones and Pyrimidinones Using Aryl Isocyanates as Building Blocks by Transition-Metal-Free C(sp2)-N Coupling",

abstract = "A class of binuclear N-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with aryl isocyanates as building blocks in the presence of a base under microwave irradiation. A nucleophilic addition followed by an unprecedented transition-metal-free C(sp2)-N coupling is proposed as a reaction pathway of this green process.",

author = "\{Quang Dao\}, \{Pham Duy\} and Cho, \{Chan Sik\}",

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doi = "10.1021/acs.joc.0c02067",

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T1 - Construction of Binuclear Benzimidazole-Fused Quinazolinones and Pyrimidinones Using Aryl Isocyanates as Building Blocks by Transition-Metal-Free C(sp2)-N Coupling

AU - Quang Dao, Pham Duy

AU - Cho, Chan Sik

PY - 2020/10/16

Y1 - 2020/10/16

N2 - A class of binuclear N-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with aryl isocyanates as building blocks in the presence of a base under microwave irradiation. A nucleophilic addition followed by an unprecedented transition-metal-free C(sp2)-N coupling is proposed as a reaction pathway of this green process.

AB - A class of binuclear N-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with aryl isocyanates as building blocks in the presence of a base under microwave irradiation. A nucleophilic addition followed by an unprecedented transition-metal-free C(sp2)-N coupling is proposed as a reaction pathway of this green process.

UR - https://www.scopus.com/pages/publications/85094590865

U2 - 10.1021/acs.joc.0c02067

DO - 10.1021/acs.joc.0c02067

M3 - Article

AN - SCOPUS:85094590865

SN - 0022-3263

VL - 85

SP - 13354

EP - 13362

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 20

ER -

Construction of Binuclear Benzimidazole-Fused Quinazolinones and Pyrimidinones Using Aryl Isocyanates as Building Blocks by Transition-Metal-Free C(sp²)-N Coupling

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