Control of a Class of Large-Scale Boolean Networks for Biological Systems Using Constant Inputs

Jung Min Yang, Kwang Hyun Cho

Research output: Contribution to journalArticlepeer-review

Abstract

Boolean networks can describe dynamics of genetic and cellular networks in a simple and abstract framework. This paper presents a constant control scheme for stabilization of large-scale Boolean networks. A number of state nodes are selected as constant control inputs so that the Boolean network can reach desirable attractors or cycles. Strongly connected components of the Boolean network are considered to reduce the computational cost. A simulation study on the problem of determining combinatorial targeted drugs for desired cellular phenotype is provided.

Original languageEnglish
Pages (from-to)300-305
Number of pages6
JournalIFAC-PapersOnLine
Volume49
Issue number26
DOIs
StatePublished - 2016

Keywords

  • Boolean networks
  • biological networks
  • constant control
  • semi-tensor product (STP)
  • stabilization
  • systems biology

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