Controlled Drug release analysis of monosized drugloaded plga microparticles by ligand-sensitized fluorescence

Hwan Gon Kim, Jin Ho Choi, Gyu Man Kim, Kyung Min Kim, Sang Hak Lee, Young Ho Kim

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A drug release monitoring method using Tb3+ ion as a fluorescent probe of controlled drug release system with monosized drug-loaded poly(lactic-co-glycolic acid) (PLGA) microparticles is presented. The luminescence properties of Tb3+-enoxacin complex were characterized by 3D fluorescence (FL) spectrum to optimize the instrumental parameters. Drug release profiles from the enoxacin-loaded monodisperse PLGA microparticles were simultaneously monitored by the presented FL method and the UV-Vis spectroscopy for the evaluation of the signal correlation. By using this novel FL method, the effects of solvents on the drug release profile of drug-loaded monodisperse PLGA microparticles were investigated.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1534-1536
Number of pages3
ISBN (Print)9780979806452
StatePublished - 2012
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 28 Oct 20121 Nov 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Conference

Conference16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Country/TerritoryJapan
CityOkinawa
Period28/10/121/11/12

Keywords

  • Controlled drug release
  • Ligand-sensitized fluorescence
  • Microfluidic flow focusing device
  • PLGA microparticle

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