Copper-catalyzed oxidative cyclization of α-hydroxyketones with o-phenylenediamines leading to quinoxalines

Chan Sik Cho, Sung Gi Oh

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

α-Hydroxyketones are oxidatively cyclized with o-phenylenediamines in toluene at 120 °C under an atmosphere of air in the presence of a catalytic amount of a copper catalyst along with powdered 4A molecular sieves to afford the corresponding quinoxalines in high yields. The reaction is applicable to a wide range of α-hydroxyketones which have various aryl and alkyl groups attached to carbonyl carbon.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalJournal of Molecular Catalysis A: Chemical
Volume276
Issue number1-2
DOIs
StatePublished - 17 Oct 2007

Keywords

  • α-Hydroxyketones
  • Copper catalyst
  • o-Phenylenediamines
  • Oxidative cyclization
  • Quinoxalines

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