Copper-Catalyzed Synthesis of Trinuclear N-Fused Hybrid Scaffolds by Double C(sp²)–N Bond Formation between 2-(2-Bromoaryl)indoles and 2-Aminoazoles

2-(2-Bromoaryl)indoles react with 2-aminoazoles by microwave irradiation in DMF in the presence of a catalytic amount of CuI and a base to produce trinuclear N-fused hybrid scaffolds, benzo[4,5]imidazo[1,2-a]indolo[1,2-c]quinazolines and imidazo[1,2-a]indolo[1,2-c]quinazolines in moderate to good yields. The reaction seems to proceed via copper-catalyzed C(sp²)-N coupling and subsequent intramolecular cyclocondensation accompanied by ammonia evolution. Complete regioselective C–N cyclization is observed with the reaction of 2-(2-bromophenyl)indole with 2-aminoazoles.