Correlation between Clinical Outcomes and Serum CA-125 Levels after Standard Treatment for Epithelial Ovarian Cancer

Juhun Lee, Jong Mi Kim, Yoon Hee Lee, Gun Oh Chong, Dae Gy Hong

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background/Aim: To analyze the relationship between clinical outcomes for epithelial ovarian cancer and serum CA-125 levels after chemotherapy in Korean women. Patients and Methods: This study included 183 patients who underwent the standard treatment regimen for epithelial ovarian cancer. They were divided into early- (I, II) and advanced-stage (III, IV) groups. Serum CA-125 level after adjuvant chemotherapy completion (post-chemotherapy; PC-CA-125) was measured. Overall survival (OS), progression-free survival (PFS), platinum-free interval (PFI), and platinum resistance were evaluated. Results: In advanced-stage group, OS, PFS, PFI, and platinum resistance were significantly correlated with PC-CA-125. In early-stage group, PFS and platinum resistance differed significantly. Cutoff value for platinum resistance was 10.45 U/ml, 10.40 U/ml, and 15.80 U/ml for study population, early stage, and advanced groups, respectively. Accuracy was 71.1%-77.1%. Conclusion: PC-CA-125 is correlated with clinical outcomes in ovarian cancer. Thus, CA-125 can be used to predict platinum resistance in ovarian cancer treatment.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalAnticancer Research
Volume42
Issue number1
DOIs
StatePublished - Jan 2022

Keywords

  • CA-125
  • Chemotherapy
  • Clinical outcomes
  • Ovarian cancer
  • Overall survival
  • Platinum resistance
  • Platinum-free interval
  • Progression-free survival

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