TY - JOUR
T1 - COVID-19 and diabetes
T2 - What do we know so far?
AU - Gangadaran, Prakash
AU - Padinjarathil, Himabindu
AU - Rajendran, Shri Hari Subhashri
AU - Jogalekar, Manasi P.
AU - Hong, Chae Moon
AU - Aruchamy, Baladhandapani
AU - Rajendran, Uma Maheswari
AU - Gurunagarajan, Sridharan
AU - Krishnan, Anand
AU - Ramani, Prasanna
AU - Subramanian, Kavimani
N1 - Publisher Copyright:
© Experimental Biology and Medicine 2022.
PY - 2022/8
Y1 - 2022/8
N2 - Coronavirus disease 2019 (COVID-19) management has been challenging for patients with comorbidities. Patients with diabetes and COVID-19, in particular, have shown severe symptoms and rapid progression of the disease. They also have a high mortality rate compared to the non-diabetic population. The high mortality rate is caused in people with diabetes who are in a pro-inflammatory condition; this could worsen COVID-19. In addition, people with diabetes have circulatory issues and COVID-19 infection can lead to further clotting problems. It is critical to understand the mechanisms underlying the adverse clinical outcomes in patients with diabetes and COVID-19. This review discusses various disease conditions contributing to poor prognosis in diabetic COVID-19 patients such as hyperglycemia, insulin resistance, impaired pancreatic function, and production of advanced glycation end products.
AB - Coronavirus disease 2019 (COVID-19) management has been challenging for patients with comorbidities. Patients with diabetes and COVID-19, in particular, have shown severe symptoms and rapid progression of the disease. They also have a high mortality rate compared to the non-diabetic population. The high mortality rate is caused in people with diabetes who are in a pro-inflammatory condition; this could worsen COVID-19. In addition, people with diabetes have circulatory issues and COVID-19 infection can lead to further clotting problems. It is critical to understand the mechanisms underlying the adverse clinical outcomes in patients with diabetes and COVID-19. This review discusses various disease conditions contributing to poor prognosis in diabetic COVID-19 patients such as hyperglycemia, insulin resistance, impaired pancreatic function, and production of advanced glycation end products.
KW - COVID-19
KW - SARS-CoV-2
KW - diabetics
KW - hyperglycemia
KW - insulin resistance
UR - http://www.scopus.com/inward/record.url?scp=85135150299&partnerID=8YFLogxK
U2 - 10.1177/15353702221108914
DO - 10.1177/15353702221108914
M3 - Review article
C2 - 35894117
AN - SCOPUS:85135150299
SN - 1535-3702
VL - 247
SP - 1330
EP - 1334
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 15
ER -
