CuI/amino acid-catalyzed coupling and cyclization of β-bromo-α, β-unsaturated amides with terminal alkynes leading to (3Z)-3- alkylidenepyrrol-1-ones

Jong Ik Son; Chan Sik Cho; Heung Jin Choi

doi:10.1002/aoc.2990

CuI/amino acid-catalyzed coupling and cyclization of β-bromo-α, β-unsaturated amides with terminal alkynes leading to (3Z)-3- alkylidenepyrrol-1-ones

Jong Ik Son, Chan Sik Cho, Heung Jin Choi

Department of Applied Chemistry

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

β-Bromo-α,β-unsaturated amides are coupled and cyclized with terminal alkynes in DMF at 110 °C in the presence of a catalytic amount of CuI and amino acid along with a base to give the corresponding (3Z)-3-alkylidenepyrrol-1-ones in moderate to good yields.

Original language	English
Pages (from-to)	380-386
Number of pages	7
Journal	Applied Organometallic Chemistry
Volume	27
Issue number	7
DOIs	https://doi.org/10.1002/aoc.2990
State	Published - Jul 2013

Keywords

β-bromo-α,β- unsaturated amide
(3Z)-3-alkylidenepyrrol-1-one
amino acid
coupling and cyclization
terminal alkyne

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10.1002/aoc.2990

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title = "CuI/amino acid-catalyzed coupling and cyclization of β-bromo-α, β-unsaturated amides with terminal alkynes leading to (3Z)-3- alkylidenepyrrol-1-ones",

abstract = "β-Bromo-α,β-unsaturated amides are coupled and cyclized with terminal alkynes in DMF at 110 °C in the presence of a catalytic amount of CuI and amino acid along with a base to give the corresponding (3Z)-3-alkylidenepyrrol-1-ones in moderate to good yields.",

keywords = "β-bromo-α,β- unsaturated amide, (3Z)-3-alkylidenepyrrol-1-one, amino acid, coupling and cyclization, terminal alkyne",

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year = "2013",

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AU - Son, Jong Ik

AU - Cho, Chan Sik

AU - Choi, Heung Jin

PY - 2013/7

Y1 - 2013/7

N2 - β-Bromo-α,β-unsaturated amides are coupled and cyclized with terminal alkynes in DMF at 110 °C in the presence of a catalytic amount of CuI and amino acid along with a base to give the corresponding (3Z)-3-alkylidenepyrrol-1-ones in moderate to good yields.

AB - β-Bromo-α,β-unsaturated amides are coupled and cyclized with terminal alkynes in DMF at 110 °C in the presence of a catalytic amount of CuI and amino acid along with a base to give the corresponding (3Z)-3-alkylidenepyrrol-1-ones in moderate to good yields.

KW - β-bromo-α,β- unsaturated amide

KW - (3Z)-3-alkylidenepyrrol-1-one

KW - amino acid

KW - coupling and cyclization

KW - terminal alkyne

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U2 - 10.1002/aoc.2990

DO - 10.1002/aoc.2990

M3 - Article

AN - SCOPUS:84879399685

SN - 0268-2605

VL - 27

SP - 380

EP - 386

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

IS - 7

ER -

CuI/amino acid-catalyzed coupling and cyclization of β-bromo-α, β-unsaturated amides with terminal alkynes leading to (3Z)-3- alkylidenepyrrol-1-ones

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Keywords

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