Current understanding of MSC-derived exosomes in the management of knee osteoarthritis

Madhan Jeyaraman; Sathish Muthu; Syed Shehabaz; Naveen Jeyaraman; Ramya Lakshmi Rajendran; Chae Moon Hong; Arulkumar Nallakumarasamy; Rathinavelpandian Perunchezhian Packkyarathinam; Shilpa Sharma; Rajni Ranjan; Manish Khanna; Byeong Cheol Ahn; Prakash Gangadaran

doi:10.1016/j.yexcr.2022.113274

Current understanding of MSC-derived exosomes in the management of knee osteoarthritis

Madhan Jeyaraman, Sathish Muthu, Syed Shehabaz, Naveen Jeyaraman, Ramya Lakshmi Rajendran, Chae Moon Hong, Arulkumar Nallakumarasamy, Rathinavelpandian Perunchezhian Packkyarathinam, Shilpa Sharma, Rajni Ranjan, Manish Khanna, Byeong Cheol Ahn, Prakash Gangadaran

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Mesenchymal stem cell-derived exosomes (MSC-Exos) have been utilized as medicinal agents or as delivery vehicles in cartilage injuries and cartilage-based diseases. Given the ongoing emergence of evidence on the effector mechanisms and methods of the utility of the MSC-Exos in knee osteoarthritis, a comprehensive review of the current evidence is the need of the hour. Hence, in this article, we review the current understanding of the role of MSC-Exos in the management of knee osteoarthritis in view of their classification, characterization, biogenesis, mechanism of action, pathways involved in their therapeutic action, in-vitro evidence on cartilage regeneration, in-vivo evidence in OA knee models and recent advances in using MSC-Exos to better streamline future research from bench to bedside for OA knee.

Original language	English
Article number	113274
Journal	Experimental Cell Research
Volume	418
Issue number	2
DOIs	https://doi.org/10.1016/j.yexcr.2022.113274
State	Published - 15 Sep 2022

Keywords

Cellular therapy
Exosomes
Extracellular vesicles
Knee
Mesenchymal stem cells
Osteoarthritis

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10.1016/j.yexcr.2022.113274

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Jeyaraman, M., Muthu, S., Shehabaz, S., Jeyaraman, N., Rajendran, R. L., Hong, C. M., Nallakumarasamy, A., Packkyarathinam, R. P., Sharma, S., Ranjan, R., Khanna, M., Ahn, B. C., & Gangadaran, P. (2022). Current understanding of MSC-derived exosomes in the management of knee osteoarthritis. Experimental Cell Research, 418(2), Article 113274. https://doi.org/10.1016/j.yexcr.2022.113274

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title = "Current understanding of MSC-derived exosomes in the management of knee osteoarthritis",

abstract = "Mesenchymal stem cell-derived exosomes (MSC-Exos) have been utilized as medicinal agents or as delivery vehicles in cartilage injuries and cartilage-based diseases. Given the ongoing emergence of evidence on the effector mechanisms and methods of the utility of the MSC-Exos in knee osteoarthritis, a comprehensive review of the current evidence is the need of the hour. Hence, in this article, we review the current understanding of the role of MSC-Exos in the management of knee osteoarthritis in view of their classification, characterization, biogenesis, mechanism of action, pathways involved in their therapeutic action, in-vitro evidence on cartilage regeneration, in-vivo evidence in OA knee models and recent advances in using MSC-Exos to better streamline future research from bench to bedside for OA knee.",

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author = "Madhan Jeyaraman and Sathish Muthu and Syed Shehabaz and Naveen Jeyaraman and Rajendran, {Ramya Lakshmi} and Hong, {Chae Moon} and Arulkumar Nallakumarasamy and Packkyarathinam, {Rathinavelpandian Perunchezhian} and Shilpa Sharma and Rajni Ranjan and Manish Khanna and Ahn, {Byeong Cheol} and Prakash Gangadaran",

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AU - Jeyaraman, Madhan

AU - Muthu, Sathish

AU - Shehabaz, Syed

AU - Jeyaraman, Naveen

AU - Rajendran, Ramya Lakshmi

AU - Hong, Chae Moon

AU - Nallakumarasamy, Arulkumar

AU - Packkyarathinam, Rathinavelpandian Perunchezhian

AU - Sharma, Shilpa

AU - Ranjan, Rajni

AU - Khanna, Manish

AU - Ahn, Byeong Cheol

AU - Gangadaran, Prakash

PY - 2022/9/15

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N2 - Mesenchymal stem cell-derived exosomes (MSC-Exos) have been utilized as medicinal agents or as delivery vehicles in cartilage injuries and cartilage-based diseases. Given the ongoing emergence of evidence on the effector mechanisms and methods of the utility of the MSC-Exos in knee osteoarthritis, a comprehensive review of the current evidence is the need of the hour. Hence, in this article, we review the current understanding of the role of MSC-Exos in the management of knee osteoarthritis in view of their classification, characterization, biogenesis, mechanism of action, pathways involved in their therapeutic action, in-vitro evidence on cartilage regeneration, in-vivo evidence in OA knee models and recent advances in using MSC-Exos to better streamline future research from bench to bedside for OA knee.

AB - Mesenchymal stem cell-derived exosomes (MSC-Exos) have been utilized as medicinal agents or as delivery vehicles in cartilage injuries and cartilage-based diseases. Given the ongoing emergence of evidence on the effector mechanisms and methods of the utility of the MSC-Exos in knee osteoarthritis, a comprehensive review of the current evidence is the need of the hour. Hence, in this article, we review the current understanding of the role of MSC-Exos in the management of knee osteoarthritis in view of their classification, characterization, biogenesis, mechanism of action, pathways involved in their therapeutic action, in-vitro evidence on cartilage regeneration, in-vivo evidence in OA knee models and recent advances in using MSC-Exos to better streamline future research from bench to bedside for OA knee.

KW - Cellular therapy

KW - Exosomes

KW - Extracellular vesicles

KW - Knee

KW - Mesenchymal stem cells

KW - Osteoarthritis

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DO - 10.1016/j.yexcr.2022.113274

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VL - 418

JO - Experimental Cell Research

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ER -

Current understanding of MSC-derived exosomes in the management of knee osteoarthritis

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