Cyclooxgenase inhibitory components from Portulaca oleracea

Jeong Ah Kim; Seo Young Yang; Sangjin Kang; Young Ho Kim

Cyclooxgenase inhibitory components from Portulaca oleracea

Jeong Ah Kim
, Seo Young Yang
, Sangjin Kang
, Young Ho Kim

Chungnam National University
CHA University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Five triterpenoids, epifriedelanol (1), friedelin (2), lupeol (3), β-sitosterol (4), daucosterol (5), and one phenyl propanoids ester, trans-docosanoyl ferulate (6) were isolated from the whole parts of Portulaca oleracea. They were determined using a combination of spectroscopic analyses ( ¹H-, ¹³C-NMR, and MS data) and evaluated for their cyclooxygenase inhibitory activity. Compound 6 exhibited inhibitory effect with IC ₅₀ values of 40.2 μM and 1.6 mM on COX-1 and COX-2 activities, respectively.

Original language	English
Pages (from-to)	22-25
Number of pages	4
Journal	Natural Product Sciences
Volume	18
Issue number	1
State	Published - Mar 2012

Keywords

Cyclooxygenase inhibitory activity
Portulaca oleracea
Trans-docosanoyl ferulate

Cite this

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title = "Cyclooxgenase inhibitory components from Portulaca oleracea",

abstract = "Five triterpenoids, epifriedelanol (1), friedelin (2), lupeol (3), β-sitosterol (4), daucosterol (5), and one phenyl propanoids ester, trans-docosanoyl ferulate (6) were isolated from the whole parts of Portulaca oleracea. They were determined using a combination of spectroscopic analyses ( 1H-, 13C-NMR, and MS data) and evaluated for their cyclooxygenase inhibitory activity. Compound 6 exhibited inhibitory effect with IC 50 values of 40.2 μM and 1.6 mM on COX-1 and COX-2 activities, respectively.",

keywords = "Cyclooxygenase inhibitory activity, Portulaca oleracea, Trans-docosanoyl ferulate",

author = "Kim, \{Jeong Ah\} and Yang, \{Seo Young\} and Sangjin Kang and Kim, \{Young Ho\}",

year = "2012",

month = mar,

language = "English",

volume = "18",

pages = "22--25",

journal = "Natural Product Sciences",

issn = "1226-3907",

publisher = "Korean Society of Pharmacognosy",

number = "1",

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TY - JOUR

T1 - Cyclooxgenase inhibitory components from Portulaca oleracea

AU - Kim, Jeong Ah

AU - Yang, Seo Young

AU - Kang, Sangjin

AU - Kim, Young Ho

PY - 2012/3

Y1 - 2012/3

N2 - Five triterpenoids, epifriedelanol (1), friedelin (2), lupeol (3), β-sitosterol (4), daucosterol (5), and one phenyl propanoids ester, trans-docosanoyl ferulate (6) were isolated from the whole parts of Portulaca oleracea. They were determined using a combination of spectroscopic analyses ( 1H-, 13C-NMR, and MS data) and evaluated for their cyclooxygenase inhibitory activity. Compound 6 exhibited inhibitory effect with IC 50 values of 40.2 μM and 1.6 mM on COX-1 and COX-2 activities, respectively.

AB - Five triterpenoids, epifriedelanol (1), friedelin (2), lupeol (3), β-sitosterol (4), daucosterol (5), and one phenyl propanoids ester, trans-docosanoyl ferulate (6) were isolated from the whole parts of Portulaca oleracea. They were determined using a combination of spectroscopic analyses ( 1H-, 13C-NMR, and MS data) and evaluated for their cyclooxygenase inhibitory activity. Compound 6 exhibited inhibitory effect with IC 50 values of 40.2 μM and 1.6 mM on COX-1 and COX-2 activities, respectively.

KW - Cyclooxygenase inhibitory activity

KW - Portulaca oleracea

KW - Trans-docosanoyl ferulate

UR - https://www.scopus.com/pages/publications/84867739150

M3 - Article

AN - SCOPUS:84867739150

SN - 1226-3907

VL - 18

SP - 22

EP - 25

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 1

ER -

Cyclooxgenase inhibitory components from Portulaca oleracea

Abstract

Keywords

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