Abstract
Mouse malignant T-lymphoma CS-21 cells can grow when cocultured with CA-12 lymph node stromal cells, but they undergo apoptotic cell death with DNA fragmentation when separated from CA-12 stromal cells. In the course of examining the effects of the soluble factor(s) secreted by CA-12 stromal cells on CS-21 cell growth, we found that cysteine produced from CA-12 stromal cells promoted CS-21 cell growth and suppressed apoptosis in the isolated culture of CS-21 cells. The expression of anti-apoptotic protein Bcl-2, however, was not induced by cysteine. These results indicate that cysteine produced from CA-12 stromal cells participates not only in the cell growth but also in the inhibition of CS-21 apoptosis without inducing the expression of Bcl-2 protein.
| Original language | English |
|---|---|
| Pages (from-to) | 837-844 |
| Number of pages | 8 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 213 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1995 |