Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia

Young Ock Kim; Kanghyun Leem; Juyoung Park; Pyeongjae Lee; Duk Kyun Ahn; Byung Chul Lee; Ho Kun Park; Kyoungho Suk; Sun Yeou Kim; Hocheol Kim

doi:10.1016/S0378-8741(01)00283-5

Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia

Young Ock Kim, Kanghyun Leem, Juyoung Park, Pyeongjae Lee, Duk Kyun Ahn, Byung Chul Lee, Ho Kun Park, Kyoungho Suk, Sun Yeou Kim, Hocheol Kim

Department of Medicine

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Based on the use of Scutellaria baicalensis for the treatment of stroke in traditional Oriental medicine, the current study was carried out to evaluate neuroprotective effects of S. baicalensis after transient global ischemia using rat 4-vessel occlusion model. Methanol extracts from the dried roots of S. baicalensis (0.1-10 mg/kg) administered intra-peritoneally significantly protected CA1 neurons against 10 min transient forebrain ischemia as demonstrated by measuring the density of neuronal cells stained with Cresyl violet. Methanol extract of S. baicalensis inhibited microglial tumor necrosis factor-alpha (TNF-α) and nitric oxide production, and protected PC12 cells from hydrogen peroxide-induced toxicity in vitro.

Original language	English
Pages (from-to)	183-188
Number of pages	6
Journal	Journal of Ethnopharmacology
Volume	77
Issue number	2-3
DOIs	https://doi.org/10.1016/S0378-8741(01)00283-5
State	Published - 2001

Keywords

Ischemia
Neuroprotection
Scutellaria baicalensis
TNF-α

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10.1016/S0378-8741(01)00283-5

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title = "Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia",

abstract = "Based on the use of Scutellaria baicalensis for the treatment of stroke in traditional Oriental medicine, the current study was carried out to evaluate neuroprotective effects of S. baicalensis after transient global ischemia using rat 4-vessel occlusion model. Methanol extracts from the dried roots of S. baicalensis (0.1-10 mg/kg) administered intra-peritoneally significantly protected CA1 neurons against 10 min transient forebrain ischemia as demonstrated by measuring the density of neuronal cells stained with Cresyl violet. Methanol extract of S. baicalensis inhibited microglial tumor necrosis factor-alpha (TNF-α) and nitric oxide production, and protected PC12 cells from hydrogen peroxide-induced toxicity in vitro.",

keywords = "Ischemia, Neuroprotection, Scutellaria baicalensis, TNF-α",

author = "Kim, {Young Ock} and Kanghyun Leem and Juyoung Park and Pyeongjae Lee and Ahn, {Duk Kyun} and Lee, {Byung Chul} and Park, {Ho Kun} and Kyoungho Suk and Kim, {Sun Yeou} and Hocheol Kim",

year = "2001",

doi = "10.1016/S0378-8741(01)00283-5",

language = "English",

volume = "77",

pages = "183--188",

journal = "Journal of Ethnopharmacology",

issn = "0378-8741",

publisher = "Elsevier Ireland Ltd",

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}

TY - JOUR

T1 - Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia

AU - Kim, Young Ock

AU - Leem, Kanghyun

AU - Park, Juyoung

AU - Lee, Pyeongjae

AU - Ahn, Duk Kyun

AU - Lee, Byung Chul

AU - Park, Ho Kun

AU - Suk, Kyoungho

AU - Kim, Sun Yeou

AU - Kim, Hocheol

PY - 2001

Y1 - 2001

N2 - Based on the use of Scutellaria baicalensis for the treatment of stroke in traditional Oriental medicine, the current study was carried out to evaluate neuroprotective effects of S. baicalensis after transient global ischemia using rat 4-vessel occlusion model. Methanol extracts from the dried roots of S. baicalensis (0.1-10 mg/kg) administered intra-peritoneally significantly protected CA1 neurons against 10 min transient forebrain ischemia as demonstrated by measuring the density of neuronal cells stained with Cresyl violet. Methanol extract of S. baicalensis inhibited microglial tumor necrosis factor-alpha (TNF-α) and nitric oxide production, and protected PC12 cells from hydrogen peroxide-induced toxicity in vitro.

AB - Based on the use of Scutellaria baicalensis for the treatment of stroke in traditional Oriental medicine, the current study was carried out to evaluate neuroprotective effects of S. baicalensis after transient global ischemia using rat 4-vessel occlusion model. Methanol extracts from the dried roots of S. baicalensis (0.1-10 mg/kg) administered intra-peritoneally significantly protected CA1 neurons against 10 min transient forebrain ischemia as demonstrated by measuring the density of neuronal cells stained with Cresyl violet. Methanol extract of S. baicalensis inhibited microglial tumor necrosis factor-alpha (TNF-α) and nitric oxide production, and protected PC12 cells from hydrogen peroxide-induced toxicity in vitro.

KW - Ischemia

KW - Neuroprotection

KW - Scutellaria baicalensis

KW - TNF-α

UR - http://www.scopus.com/inward/record.url?scp=0034882904&partnerID=8YFLogxK

U2 - 10.1016/S0378-8741(01)00283-5

DO - 10.1016/S0378-8741(01)00283-5

M3 - Article

C2 - 11535362

AN - SCOPUS:0034882904

SN - 0378-8741

VL - 77

SP - 183

EP - 188

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

IS - 2-3

ER -

Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia

Abstract

Keywords

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