Cytotoxic and apoptosis-inducing activities against human lung cancer cell lines of cassaine diterpenoids from the bark of Erythrophleum fordii

Manh Tuan Ha, Manh Hung Tran, Thien Thuong Phuong, Jeong Ah Kim, Mi Hee Woo, Jae Sue Choi, Suhyun Lee, Jeong Hyung Lee, Hyeong Kyu Lee, Byung Sun Min

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15 Scopus citations

Abstract

A phytochemical investigation into the bark of Erythrophleum fordii yielded four new compounds, two new cassaine diterpenoids (erythrofordin T and U, 1 and 2) and two new cassaine diterpenoid amines (erythroformine A and B, 6 and 7), as well as nine known compounds. We report for the first time the isolation of erythrofordin V (3) from a natural source and that of the remaining eight known diterpenoids (4–5, 8–13) from E. fordii. All structures were elucidated using spectroscopic analysis. Cytotoxic activity of the isolated compounds (1–13) was examined in vitro against three non-small cell lung cancer cell lines (A549, NCI-H1975, and NCI-H1229) using the MTT assay. Cassaine diterpene amines (6–10, 12, 13) exhibited potent cytotoxic activity against all three cell lines with IC50 values between 0.4 μM and 5.9 μM. Erythroformine B (7) significantly induced apoptosis in all three cancer cells in a concentration-dependent manner.

Original languageEnglish
Pages (from-to)2946-2952
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Volume27
Issue number13
DOIs
StatePublished - 2017

Keywords

  • Apoptosis
  • Cassaine diterpene alkaloid
  • Erythrophleum fordii
  • Non-small cell lung cancers (NSCLC)

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