Cytotoxic and neuroprotective biflavonoids from the fruit of Rhus parviflora

Sabina Shrestha; Ji Hae Park; Dae Young Lee; Jin Gyeong Cho; Woo Duck Seo; Hee Cheol Kang; Ki Hyun Yoo; In Sik Chung; Yong Jin Jeon; Seung Woo Yeon; Nam In Baek

doi:10.1007/s13765-012-2090-9

Cytotoxic and neuroprotective biflavonoids from the fruit of Rhus parviflora

Sabina Shrestha, Ji Hae Park, Dae Young Lee, Jin Gyeong Cho, Woo Duck Seo, Hee Cheol Kang, Ki Hyun Yoo, In Sik Chung, Yong Jin Jeon, Seung Woo Yeon, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Six biflavonoids, succedaneaflavanone (1), mesuaferrone B (2), rhusflavanone (3), rhusflavone (4), agathisflavone (5), and cupressuflavone (6), were isolated from the fruits of Rhus parviflora. The chemical structures of the compounds were determined based on NMR, fast atom bombardment mass spectrometry, and IR. Biflavonoid compounds were evaluated for cytotoxicity against human cancer cell lines, including human colon carcinoma (HCT-116), human breast carcinoma (MCF-7), and human cervical carcinoma (HeLa). Biflavonoids 2, 3, and 5 showed significant cytotoxicity with IC₅₀ values of 17.25 μM (mesuaferrone B against HCT-116), 17.50 μM (rhusflavone against MCF-7), and 15.20 μM (agathisflavone against HeLa). Compound 5 showed inhibition of β-secretase activity at a 10 μM concentration. Compound 6 showed inhibition of cyclin-dependent kinases (CDK2 and CDK5) with IC₅₀ values of 18.58 and 9.29 μM, respectively.

Original language	English
Pages (from-to)	557-562
Number of pages	6
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume	55
Issue number	4
DOIs	https://doi.org/10.1007/s13765-012-2090-9
State	Published - Aug 2012

Keywords

agathisflavone
biflavonoid
cupressuflavone
cytotoxicity
mesuaferrone B
neuroprotection
rhusflavanone
rhusflavone
succedaneaflavanone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13765-012-2090-9

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title = "Cytotoxic and neuroprotective biflavonoids from the fruit of Rhus parviflora",

abstract = "Six biflavonoids, succedaneaflavanone (1), mesuaferrone B (2), rhusflavanone (3), rhusflavone (4), agathisflavone (5), and cupressuflavone (6), were isolated from the fruits of Rhus parviflora. The chemical structures of the compounds were determined based on NMR, fast atom bombardment mass spectrometry, and IR. Biflavonoid compounds were evaluated for cytotoxicity against human cancer cell lines, including human colon carcinoma (HCT-116), human breast carcinoma (MCF-7), and human cervical carcinoma (HeLa). Biflavonoids 2, 3, and 5 showed significant cytotoxicity with IC50 values of 17.25 μM (mesuaferrone B against HCT-116), 17.50 μM (rhusflavone against MCF-7), and 15.20 μM (agathisflavone against HeLa). Compound 5 showed inhibition of β-secretase activity at a 10 μM concentration. Compound 6 showed inhibition of cyclin-dependent kinases (CDK2 and CDK5) with IC50 values of 18.58 and 9.29 μM, respectively.",

keywords = "agathisflavone, biflavonoid, cupressuflavone, cytotoxicity, mesuaferrone B, neuroprotection, rhusflavanone, rhusflavone, succedaneaflavanone",

author = "Sabina Shrestha and Park, {Ji Hae} and Lee, {Dae Young} and Cho, {Jin Gyeong} and Seo, {Woo Duck} and Kang, {Hee Cheol} and Yoo, {Ki Hyun} and Chung, {In Sik} and Jeon, {Yong Jin} and Yeon, {Seung Woo} and Baek, {Nam In}",

year = "2012",

month = aug,

doi = "10.1007/s13765-012-2090-9",

language = "English",

volume = "55",

pages = "557--562",

journal = "Journal of the Korean Society for Applied Biological Chemistry",

issn = "1738-2203",

publisher = "Springer Netherlands",

number = "4",

}

TY - JOUR

T1 - Cytotoxic and neuroprotective biflavonoids from the fruit of Rhus parviflora

AU - Shrestha, Sabina

AU - Park, Ji Hae

AU - Lee, Dae Young

AU - Cho, Jin Gyeong

AU - Seo, Woo Duck

AU - Kang, Hee Cheol

AU - Yoo, Ki Hyun

AU - Chung, In Sik

AU - Jeon, Yong Jin

AU - Yeon, Seung Woo

AU - Baek, Nam In

PY - 2012/8

Y1 - 2012/8

N2 - Six biflavonoids, succedaneaflavanone (1), mesuaferrone B (2), rhusflavanone (3), rhusflavone (4), agathisflavone (5), and cupressuflavone (6), were isolated from the fruits of Rhus parviflora. The chemical structures of the compounds were determined based on NMR, fast atom bombardment mass spectrometry, and IR. Biflavonoid compounds were evaluated for cytotoxicity against human cancer cell lines, including human colon carcinoma (HCT-116), human breast carcinoma (MCF-7), and human cervical carcinoma (HeLa). Biflavonoids 2, 3, and 5 showed significant cytotoxicity with IC50 values of 17.25 μM (mesuaferrone B against HCT-116), 17.50 μM (rhusflavone against MCF-7), and 15.20 μM (agathisflavone against HeLa). Compound 5 showed inhibition of β-secretase activity at a 10 μM concentration. Compound 6 showed inhibition of cyclin-dependent kinases (CDK2 and CDK5) with IC50 values of 18.58 and 9.29 μM, respectively.

AB - Six biflavonoids, succedaneaflavanone (1), mesuaferrone B (2), rhusflavanone (3), rhusflavone (4), agathisflavone (5), and cupressuflavone (6), were isolated from the fruits of Rhus parviflora. The chemical structures of the compounds were determined based on NMR, fast atom bombardment mass spectrometry, and IR. Biflavonoid compounds were evaluated for cytotoxicity against human cancer cell lines, including human colon carcinoma (HCT-116), human breast carcinoma (MCF-7), and human cervical carcinoma (HeLa). Biflavonoids 2, 3, and 5 showed significant cytotoxicity with IC50 values of 17.25 μM (mesuaferrone B against HCT-116), 17.50 μM (rhusflavone against MCF-7), and 15.20 μM (agathisflavone against HeLa). Compound 5 showed inhibition of β-secretase activity at a 10 μM concentration. Compound 6 showed inhibition of cyclin-dependent kinases (CDK2 and CDK5) with IC50 values of 18.58 and 9.29 μM, respectively.

KW - agathisflavone

KW - biflavonoid

KW - cupressuflavone

KW - cytotoxicity

KW - mesuaferrone B

KW - neuroprotection

KW - rhusflavanone

KW - rhusflavone

KW - succedaneaflavanone

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U2 - 10.1007/s13765-012-2090-9

DO - 10.1007/s13765-012-2090-9

M3 - Article

AN - SCOPUS:84866087560

SN - 1738-2203

VL - 55

SP - 557

EP - 562

JO - Journal of the Korean Society for Applied Biological Chemistry

JF - Journal of the Korean Society for Applied Biological Chemistry

IS - 4

ER -

Cytotoxic and neuroprotective biflavonoids from the fruit of Rhus parviflora

Abstract

Keywords

UN SDGs

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