Cytotoxic triterpene saponins from the mangrove Aegiceras corniculatum

Le Ba Vinh; Nguyen Thi Minh Nguyet; Seo Young Yang; Jang Hoon Kim; Nguyen Van Thanh; Nguyen Xuan Cuong; Nguyen Hoai Nam; Chau Van Minh; Inkyu Hwang; Young Ho Kim

doi:10.1080/14786419.2017.1402320

Cytotoxic triterpene saponins from the mangrove Aegiceras corniculatum

Le Ba Vinh, Nguyen Thi Minh Nguyet, Seo Young Yang, Jang Hoon Kim, Nguyen Van Thanh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh, Inkyu Hwang, Young Ho Kim

Department of Biology Education

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Using various chromatographic separations, sixteen compounds, including one new triterpene saponin named aegicoroside A (1), were isolated from the leaves of the Vietnamese mangrove Aegiceras corniculatum. Their structures were determined by spectroscopic methods such as 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities of the isolated compounds against MCF7 (breast), HCT116 (colon), B16F10 (melanoma), and A549 (adenocarcinoma) cancer cell lines were also evaluated. Strong cytotoxicity was observed for sakurasosaponin (2) against all four cancer cell lines and for sakurasosaponin methyl ester (3) against MCF7, A549, and HCT116 cell lines with IC ₅₀ values ranging from 2.89 ± 0.02 to 9.86 ± 0.21 μM.

Original language	English
Pages (from-to)	628-634
Number of pages	7
Journal	Natural Product Research
Volume	33
Issue number	5
DOIs	https://doi.org/10.1080/14786419.2017.1402320
State	Published - 4 Mar 2019

Keywords

Aegiceras corniculatum
cytotoxic activity
triterpene saponin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/14786419.2017.1402320

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title = "Cytotoxic triterpene saponins from the mangrove Aegiceras corniculatum",

abstract = " Using various chromatographic separations, sixteen compounds, including one new triterpene saponin named aegicoroside A (1), were isolated from the leaves of the Vietnamese mangrove Aegiceras corniculatum. Their structures were determined by spectroscopic methods such as 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities of the isolated compounds against MCF7 (breast), HCT116 (colon), B16F10 (melanoma), and A549 (adenocarcinoma) cancer cell lines were also evaluated. Strong cytotoxicity was observed for sakurasosaponin (2) against all four cancer cell lines and for sakurasosaponin methyl ester (3) against MCF7, A549, and HCT116 cell lines with IC 50 values ranging from 2.89 ± 0.02 to 9.86 ± 0.21 μM.",

keywords = "Aegiceras corniculatum, cytotoxic activity, triterpene saponin",

author = "Vinh, {Le Ba} and Nguyet, {Nguyen Thi Minh} and Yang, {Seo Young} and Kim, {Jang Hoon} and Thanh, {Nguyen Van} and Cuong, {Nguyen Xuan} and Nam, {Nguyen Hoai} and Minh, {Chau Van} and Inkyu Hwang and Kim, {Young Ho}",

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year = "2019",

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doi = "10.1080/14786419.2017.1402320",

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T1 - Cytotoxic triterpene saponins from the mangrove Aegiceras corniculatum

AU - Vinh, Le Ba

AU - Nguyet, Nguyen Thi Minh

AU - Yang, Seo Young

AU - Kim, Jang Hoon

AU - Thanh, Nguyen Van

AU - Cuong, Nguyen Xuan

AU - Nam, Nguyen Hoai

AU - Minh, Chau Van

AU - Hwang, Inkyu

AU - Kim, Young Ho

PY - 2019/3/4

Y1 - 2019/3/4

N2 - Using various chromatographic separations, sixteen compounds, including one new triterpene saponin named aegicoroside A (1), were isolated from the leaves of the Vietnamese mangrove Aegiceras corniculatum. Their structures were determined by spectroscopic methods such as 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities of the isolated compounds against MCF7 (breast), HCT116 (colon), B16F10 (melanoma), and A549 (adenocarcinoma) cancer cell lines were also evaluated. Strong cytotoxicity was observed for sakurasosaponin (2) against all four cancer cell lines and for sakurasosaponin methyl ester (3) against MCF7, A549, and HCT116 cell lines with IC 50 values ranging from 2.89 ± 0.02 to 9.86 ± 0.21 μM.

AB - Using various chromatographic separations, sixteen compounds, including one new triterpene saponin named aegicoroside A (1), were isolated from the leaves of the Vietnamese mangrove Aegiceras corniculatum. Their structures were determined by spectroscopic methods such as 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities of the isolated compounds against MCF7 (breast), HCT116 (colon), B16F10 (melanoma), and A549 (adenocarcinoma) cancer cell lines were also evaluated. Strong cytotoxicity was observed for sakurasosaponin (2) against all four cancer cell lines and for sakurasosaponin methyl ester (3) against MCF7, A549, and HCT116 cell lines with IC 50 values ranging from 2.89 ± 0.02 to 9.86 ± 0.21 μM.

KW - Aegiceras corniculatum

KW - cytotoxic activity

KW - triterpene saponin

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DO - 10.1080/14786419.2017.1402320

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AN - SCOPUS:85034266122

SN - 1478-6419

VL - 33

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JO - Natural Product Research

JF - Natural Product Research

IS - 5

ER -

Cytotoxic triterpene saponins from the mangrove Aegiceras corniculatum

Abstract

Keywords

UN SDGs

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