Cytotoxicity and antimicrobial effect of Ag doped hydroxyapatite

In the synthesis of antimicrobial hydroxyapatite doped with silver, the amount of silver is the critical element affecting its properties. And also depending on the synthesis route, not only the amount of silver but also the release behavior was found to be altered. The cytotoxicity, antimicrobial effects and stability of effects were observed with Ag doped hydroxyapatite fabricated through various routes. The results suggested that the optimal antimicrobial property with none or mild cytotoxicity may be produced by modulating not only the doped silver amount but also their shape and synthesis route.