Cytotoxicity of neolignans from Magnolia obovata fruits

Kyeong Hwa Seo; Dae Young Lee; Rak Hun Jeong; Ki Hyun Yoo; In Sik Chung; Geum Soog Kim; Woo Duck Seo; Hee Cheol Kang; Eun Mi Ahn; Nam In Baek

doi:10.3839/jabc.2013.028

Cytotoxicity of neolignans from Magnolia obovata fruits

Kyeong Hwa Seo, Dae Young Lee, Rak Hun Jeong, Ki Hyun Yoo, In Sik Chung, Geum Soog Kim, Woo Duck Seo, Hee Cheol Kang, Eun Mi Ahn, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Repeated SiO ₂ and octadecyl silica gel (ODS) column chromatographies of the EtOAc fraction from Magnolia obovata fruits, 10 neolignans, named magnolol (1), honokiol (2), isoobovatol (3), isomagnolol (4), obovatol (5), obovatal (6), 9- methoxyobovatol (7), magnobovatol (8), obovaaldehyde (9), and 2-hydroxyobovaaldehyde (10) were isolated and identified. All isolated compounds were evaluated for in vitro cytotoxicity against seven human cancer cell lines.

Original language	English
Pages (from-to)	179-181
Number of pages	3
Journal	Journal of Applied Biological Chemistry
Volume	56
Issue number	3
DOIs	https://doi.org/10.3839/jabc.2013.028
State	Published - 2013

Keywords

Cancer cell
Cytotoxicity
Honokiol
Magnolia obovata
Magnolol
Neolignan

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10.3839/jabc.2013.028

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title = "Cytotoxicity of neolignans from Magnolia obovata fruits",

abstract = " Repeated SiO 2 and octadecyl silica gel (ODS) column chromatographies of the EtOAc fraction from Magnolia obovata fruits, 10 neolignans, named magnolol (1), honokiol (2), isoobovatol (3), isomagnolol (4), obovatol (5), obovatal (6), 9- methoxyobovatol (7), magnobovatol (8), obovaaldehyde (9), and 2-hydroxyobovaaldehyde (10) were isolated and identified. All isolated compounds were evaluated for in vitro cytotoxicity against seven human cancer cell lines.",

keywords = "Cancer cell, Cytotoxicity, Honokiol, Magnolia obovata, Magnolol, Neolignan",

author = "Seo, {Kyeong Hwa} and Lee, {Dae Young} and Jeong, {Rak Hun} and Yoo, {Ki Hyun} and Chung, {In Sik} and Kim, {Geum Soog} and Seo, {Woo Duck} and Kang, {Hee Cheol} and Ahn, {Eun Mi} and Baek, {Nam In}",

year = "2013",

doi = "10.3839/jabc.2013.028",

language = "English",

volume = "56",

pages = "179--181",

journal = "Journal of Applied Biological Chemistry",

issn = "1976-0442",

publisher = "The Korean Society for Applied Biological Chemistry",

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TY - JOUR

T1 - Cytotoxicity of neolignans from Magnolia obovata fruits

AU - Seo, Kyeong Hwa

AU - Lee, Dae Young

AU - Jeong, Rak Hun

AU - Yoo, Ki Hyun

AU - Chung, In Sik

AU - Kim, Geum Soog

AU - Seo, Woo Duck

AU - Kang, Hee Cheol

AU - Ahn, Eun Mi

AU - Baek, Nam In

PY - 2013

Y1 - 2013

N2 - Repeated SiO 2 and octadecyl silica gel (ODS) column chromatographies of the EtOAc fraction from Magnolia obovata fruits, 10 neolignans, named magnolol (1), honokiol (2), isoobovatol (3), isomagnolol (4), obovatol (5), obovatal (6), 9- methoxyobovatol (7), magnobovatol (8), obovaaldehyde (9), and 2-hydroxyobovaaldehyde (10) were isolated and identified. All isolated compounds were evaluated for in vitro cytotoxicity against seven human cancer cell lines.

AB - Repeated SiO 2 and octadecyl silica gel (ODS) column chromatographies of the EtOAc fraction from Magnolia obovata fruits, 10 neolignans, named magnolol (1), honokiol (2), isoobovatol (3), isomagnolol (4), obovatol (5), obovatal (6), 9- methoxyobovatol (7), magnobovatol (8), obovaaldehyde (9), and 2-hydroxyobovaaldehyde (10) were isolated and identified. All isolated compounds were evaluated for in vitro cytotoxicity against seven human cancer cell lines.

KW - Cancer cell

KW - Cytotoxicity

KW - Honokiol

KW - Magnolia obovata

KW - Magnolol

KW - Neolignan

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U2 - 10.3839/jabc.2013.028

DO - 10.3839/jabc.2013.028

M3 - Article

AN - SCOPUS:84940356484

SN - 1976-0442

VL - 56

SP - 179

EP - 181

JO - Journal of Applied Biological Chemistry

JF - Journal of Applied Biological Chemistry

IS - 3

ER -

Cytotoxicity of neolignans from Magnolia obovata fruits

Abstract

Keywords

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