Cytotoxicity of trichothecenes to human solid tumor cells in vitro

Sang Un Choi; Eun Jung Choi; Kwang Hee Kim; Nam Young Kim; Byoung Mog Kwon; Sung Uk Kim; Song Hae Bok; So Young Lee; Chong Ock Lee

doi:10.1007/BF02976812

Cytotoxicity of trichothecenes to human solid tumor cells in vitro

Sang Un Choi, Eun Jung Choi, Kwang Hee Kim, Nam Young Kim, Byoung Mog Kwon, Sung Uk Kim, Song Hae Bok, So Young Lee, Chong Ock Lee

Department of Innovative Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The trichothecenes are sesquiterpenoid mycotoxins characterized by the 12,13-epoxytrichothec-9-ene ring system. We have tested cytotoxicity of several naturally-occurring or synthesized trichothecenes against human solid tumor cell lines. Among them, trichothecin (I) and 4-β-Acetoxy-12,13-epoxytrichothec-9-ene (trichodermin, II) exhibited highly cytotoxic activities. 4-β-Hydroxy-12,13-epoxytrichothec-9-ene (trichodermol, III) and 4-β-Methoxy-12,13-epoxytrichothec-9-ene (IV) had mild cytotoxicities. But 12,13-Epoxytrichothec-9-ene-4-one (V) and 4-α-Hydroxy-12,13-epoxytrichothec-9-ene(VI) had no cytotoxicities up to 10 μg/ml. And in the tested cell lines, HCT15 colon cancer cell line was the most sensitive to all tested trichothecenes.

Original language	English
Pages (from-to)	6-11
Number of pages	6
Journal	Archives of Pharmacal Research
Volume	19
Issue number	1
DOIs	https://doi.org/10.1007/BF02976812
State	Published - 1996

Keywords

Cytotoxicity
Gliocladium
Human tumor cell line
Trichothecenes
Trichothecium

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10.1007/BF02976812

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title = "Cytotoxicity of trichothecenes to human solid tumor cells in vitro",

abstract = "The trichothecenes are sesquiterpenoid mycotoxins characterized by the 12,13-epoxytrichothec-9-ene ring system. We have tested cytotoxicity of several naturally-occurring or synthesized trichothecenes against human solid tumor cell lines. Among them, trichothecin (I) and 4-β-Acetoxy-12,13-epoxytrichothec-9-ene (trichodermin, II) exhibited highly cytotoxic activities. 4-β-Hydroxy-12,13-epoxytrichothec-9-ene (trichodermol, III) and 4-β-Methoxy-12,13-epoxytrichothec-9-ene (IV) had mild cytotoxicities. But 12,13-Epoxytrichothec-9-ene-4-one (V) and 4-α-Hydroxy-12,13-epoxytrichothec-9-ene(VI) had no cytotoxicities up to 10 μg/ml. And in the tested cell lines, HCT15 colon cancer cell line was the most sensitive to all tested trichothecenes.",

keywords = "Cytotoxicity, Gliocladium, Human tumor cell line, Trichothecenes, Trichothecium",

author = "Choi, {Sang Un} and Choi, {Eun Jung} and Kim, {Kwang Hee} and Kim, {Nam Young} and Kwon, {Byoung Mog} and Kim, {Sung Uk} and Bok, {Song Hae} and Lee, {So Young} and Lee, {Chong Ock}",

year = "1996",

doi = "10.1007/BF02976812",

language = "English",

volume = "19",

pages = "6--11",

journal = "Archives of Pharmacal Research",

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publisher = "Pharmaceutical Society of Korea",

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T1 - Cytotoxicity of trichothecenes to human solid tumor cells in vitro

AU - Choi, Sang Un

AU - Choi, Eun Jung

AU - Kim, Kwang Hee

AU - Kim, Nam Young

AU - Kwon, Byoung Mog

AU - Kim, Sung Uk

AU - Bok, Song Hae

AU - Lee, So Young

AU - Lee, Chong Ock

PY - 1996

Y1 - 1996

N2 - The trichothecenes are sesquiterpenoid mycotoxins characterized by the 12,13-epoxytrichothec-9-ene ring system. We have tested cytotoxicity of several naturally-occurring or synthesized trichothecenes against human solid tumor cell lines. Among them, trichothecin (I) and 4-β-Acetoxy-12,13-epoxytrichothec-9-ene (trichodermin, II) exhibited highly cytotoxic activities. 4-β-Hydroxy-12,13-epoxytrichothec-9-ene (trichodermol, III) and 4-β-Methoxy-12,13-epoxytrichothec-9-ene (IV) had mild cytotoxicities. But 12,13-Epoxytrichothec-9-ene-4-one (V) and 4-α-Hydroxy-12,13-epoxytrichothec-9-ene(VI) had no cytotoxicities up to 10 μg/ml. And in the tested cell lines, HCT15 colon cancer cell line was the most sensitive to all tested trichothecenes.

AB - The trichothecenes are sesquiterpenoid mycotoxins characterized by the 12,13-epoxytrichothec-9-ene ring system. We have tested cytotoxicity of several naturally-occurring or synthesized trichothecenes against human solid tumor cell lines. Among them, trichothecin (I) and 4-β-Acetoxy-12,13-epoxytrichothec-9-ene (trichodermin, II) exhibited highly cytotoxic activities. 4-β-Hydroxy-12,13-epoxytrichothec-9-ene (trichodermol, III) and 4-β-Methoxy-12,13-epoxytrichothec-9-ene (IV) had mild cytotoxicities. But 12,13-Epoxytrichothec-9-ene-4-one (V) and 4-α-Hydroxy-12,13-epoxytrichothec-9-ene(VI) had no cytotoxicities up to 10 μg/ml. And in the tested cell lines, HCT15 colon cancer cell line was the most sensitive to all tested trichothecenes.

KW - Cytotoxicity

KW - Gliocladium

KW - Human tumor cell line

KW - Trichothecenes

KW - Trichothecium

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U2 - 10.1007/BF02976812

DO - 10.1007/BF02976812

M3 - Article

AN - SCOPUS:0030438551

SN - 0253-6269

VL - 19

SP - 6

EP - 11

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 1

ER -

Cytotoxicity of trichothecenes to human solid tumor cells in vitro

Abstract

Keywords

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