TY - JOUR
T1 - d-Glucuronic Acid-Coated Ultrasmall Paramagnetic Ln2O3 (Ln = Tb, Dy, and Ho) Nanoparticles
T2 - Magnetic Properties, Water Proton Relaxivities, and Fluorescence Properties
AU - Marasini, Shanti
AU - Yue, Huan
AU - Ho, Son Long
AU - Jung, Ki Hye
AU - Park, Ji Ae
AU - Cha, Hyunsil
AU - Ghazanfari, Adibehalsadat
AU - Ahmad, Mohammad Yaseen
AU - Liu, Shuwen
AU - Jang, Yeong Ji
AU - Miao, Xu
AU - Chae, Kwon Seok
AU - Chang, Yongmin
AU - Lee, Gang Ho
N1 - Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/9/15
Y1 - 2019/9/15
N2 - Many of the lanthanide-based nanoparticles are valuable in magnetic resonance imaging (MRI) because they have excellent magnetic properties that make them suitable for MRI contrast agents, while some of them have additional optical properties and thus can serve as fluorescence imaging (FI) agents as well. Herein, we synthesized d-glucuronic acid-coated ultrasmall Ln2O3 (Ln = Tb, Dy, and Ho) nanoparticles with average diameters of ∼ 2 nm. All the nanoparticles showed unsaturated but appreciable magnetization of ∼ 4 emu/g at an applied field of 1.8 T at room temperature, and consequently, high transverse water proton relaxivities (r2) of ∼ 7 s–1 mm–1 at 1.5 T, ∼ 35 s–1 mm–1 at 3.0 T, and ∼ 55 s–1 mm–1 at 9.4 T with negligible longitudinal water proton relaxivities (r1), thus being eligible for use as T2 MRI contrast agents at high MR fields. In addition, d-glucuronic acid-coated ultrasmall Tb2O3 nanoparticles exhibited fluorescence in the green region, useful for dual-modal imaging.
AB - Many of the lanthanide-based nanoparticles are valuable in magnetic resonance imaging (MRI) because they have excellent magnetic properties that make them suitable for MRI contrast agents, while some of them have additional optical properties and thus can serve as fluorescence imaging (FI) agents as well. Herein, we synthesized d-glucuronic acid-coated ultrasmall Ln2O3 (Ln = Tb, Dy, and Ho) nanoparticles with average diameters of ∼ 2 nm. All the nanoparticles showed unsaturated but appreciable magnetization of ∼ 4 emu/g at an applied field of 1.8 T at room temperature, and consequently, high transverse water proton relaxivities (r2) of ∼ 7 s–1 mm–1 at 1.5 T, ∼ 35 s–1 mm–1 at 3.0 T, and ∼ 55 s–1 mm–1 at 9.4 T with negligible longitudinal water proton relaxivities (r1), thus being eligible for use as T2 MRI contrast agents at high MR fields. In addition, d-glucuronic acid-coated ultrasmall Tb2O3 nanoparticles exhibited fluorescence in the green region, useful for dual-modal imaging.
KW - Fluorescence
KW - Imaging agents
KW - Lanthanide oxides
KW - Magnetic properties
KW - Nanoparticles
KW - Transverse relaxation
UR - http://www.scopus.com/inward/record.url?scp=85071652444&partnerID=8YFLogxK
U2 - 10.1002/ejic.201900378
DO - 10.1002/ejic.201900378
M3 - Article
AN - SCOPUS:85071652444
SN - 1434-1948
VL - 2019
SP - 3832
EP - 3839
JO - European Journal of Inorganic Chemistry
JF - European Journal of Inorganic Chemistry
IS - 34
ER -