DA-9601 decreases immediate-type allergic reaction and tumor necrosis factor-α production

Hyo Hyun Park, Sug Hyun Kim, Soyoung Lee, Jin Young Moon, Won Hwan Park, Cheorl Ho Kim, Myung Chung Jae, Tae Young Oh, Chang Duk Jun, Sang Hyun Kim

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic disease is a very important subject in human health. The formulated ethanol extract of Artemisia asiatica Nakai (DA-9601) has been reported to have antioxidative and anti-inflammatory activities. In this report, we investigated the effect of DA-9601 on the immediate-type allergic reaction and studied its possible mechanisms of action, focusing on the mast cell-mediated allergic reaction. DA-9601 inhibited compound 48/80-induced systemic anaphylactic reactions and serum histamine release in mice. DA-9601 decreased the IgE-mediated passive cutaneous anaphylaxis, the model of local allergic reaction in vivo. DA-9601 dose-dependently reduced histamine release from mast cells activated by compound 48/80 or IgE. Furthermore, DA-9601 decreased the gene expression and production of tumor necrosis factor (TNF)-α in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. These findings provide evidence that DA-9601 could be a candidate as an anti-allergic agent.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalJournal of Health Science
Volume52
Issue number4
DOIs
StatePublished - 2006

Keywords

  • DA-9601
  • Immediate-type allergic reaction
  • Mast cells
  • Tumor necrosis factor-α

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