Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells

Nguyen Huu Tung; Gyu Yong Song; Jeong Ah Kim; Jae Hee Hyun; Hee Kyoung Kang; Young Ho Kim

doi:10.1016/j.bmcl.2009.10.110

Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells

Nguyen Huu Tung
, Gyu Yong Song
, Jeong Ah Kim
, Jae Hee Hyun
, Hee Kyoung Kang
, Young Ho Kim

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Six dammarane-type saponins, including three new compounds, floralginsenosides Ta-Tc (1-3), and three known, floralginsenoside Td (4), ginsenoside F₁ (5), and ginsenoside F₅ (6), were isolated from the flower buds of Panax ginseng. Floralginsenoside Td (4) was first isolated from natural plant sources. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Compounds 1, 5, and 6 showed cytotoxic activities towards the HL-60 human leukemia cell line with respective IC₅₀ values of 36.3, 23.2, and 62.4 μM. In addition, after the HL-60 cells were treated with these compounds, several apoptosis events, including chromatin condensation and increase in the population of sub-G1 hypodiploid cells, were observed.

Original language	English
Pages (from-to)	309-314
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2009.10.110
State	Published - 1 Jan 2010

Keywords

Apoptosis
Araliaceae
Cytotoxic activity
Dammarane-type saponin
Floralginsenoside
Ginsenoside
Panax ginseng

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10.1016/j.bmcl.2009.10.110

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title = "Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells",

abstract = "Six dammarane-type saponins, including three new compounds, floralginsenosides Ta-Tc (1-3), and three known, floralginsenoside Td (4), ginsenoside F1 (5), and ginsenoside F5 (6), were isolated from the flower buds of Panax ginseng. Floralginsenoside Td (4) was first isolated from natural plant sources. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Compounds 1, 5, and 6 showed cytotoxic activities towards the HL-60 human leukemia cell line with respective IC50 values of 36.3, 23.2, and 62.4 μM. In addition, after the HL-60 cells were treated with these compounds, several apoptosis events, including chromatin condensation and increase in the population of sub-G1 hypodiploid cells, were observed.",

keywords = "Apoptosis, Araliaceae, Cytotoxic activity, Dammarane-type saponin, Floralginsenoside, Ginsenoside, Panax ginseng",

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doi = "10.1016/j.bmcl.2009.10.110",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells

AU - Tung, Nguyen Huu

AU - Song, Gyu Yong

AU - Kim, Jeong Ah

AU - Hyun, Jae Hee

AU - Kang, Hee Kyoung

AU - Kim, Young Ho

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Six dammarane-type saponins, including three new compounds, floralginsenosides Ta-Tc (1-3), and three known, floralginsenoside Td (4), ginsenoside F1 (5), and ginsenoside F5 (6), were isolated from the flower buds of Panax ginseng. Floralginsenoside Td (4) was first isolated from natural plant sources. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Compounds 1, 5, and 6 showed cytotoxic activities towards the HL-60 human leukemia cell line with respective IC50 values of 36.3, 23.2, and 62.4 μM. In addition, after the HL-60 cells were treated with these compounds, several apoptosis events, including chromatin condensation and increase in the population of sub-G1 hypodiploid cells, were observed.

AB - Six dammarane-type saponins, including three new compounds, floralginsenosides Ta-Tc (1-3), and three known, floralginsenoside Td (4), ginsenoside F1 (5), and ginsenoside F5 (6), were isolated from the flower buds of Panax ginseng. Floralginsenoside Td (4) was first isolated from natural plant sources. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Compounds 1, 5, and 6 showed cytotoxic activities towards the HL-60 human leukemia cell line with respective IC50 values of 36.3, 23.2, and 62.4 μM. In addition, after the HL-60 cells were treated with these compounds, several apoptosis events, including chromatin condensation and increase in the population of sub-G1 hypodiploid cells, were observed.

KW - Apoptosis

KW - Araliaceae

KW - Cytotoxic activity

KW - Dammarane-type saponin

KW - Floralginsenoside

KW - Ginsenoside

KW - Panax ginseng

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DO - 10.1016/j.bmcl.2009.10.110

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AN - SCOPUS:72049084474

SN - 0960-894X

VL - 20

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EP - 314

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells

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Keywords

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