Daunorubicin efflux assay in determining multidrug resistance of patients with acute myeloid leukemia

Dong Hwan Kim; Nan Young Lee; Jong Gwang Kim; Sang Kyun Sohn; Dong Il Won; Jang Soo Suh; Gun Soo Lee; Shung Chull Chae; Kyu Bo Lee

doi:10.1080/10428190400010759

Daunorubicin efflux assay in determining multidrug resistance of patients with acute myeloid leukemia

Dong Hwan Kim, Nan Young Lee, Jong Gwang Kim, Sang Kyun Sohn, Dong Il Won, Jang Soo Suh, Gun Soo Lee, Shung Chull Chae, Kyu Bo Lee

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We evaluated the predictive value of mdr1 mRNA RT-PCR, P-glycoprotein (Pgp), and Daunorubicin efflux assays as regards achieving complete remission (CR), overall survival (OS), and leukemia-free survival (LFS) in 72 patients with AML. mdr1 mRNA, Pgp, and Efflux were expressed in 55.6%, 36.1%, and 33.3%. Efflux⁺ was associated with a lower CR rate (P=0.006). A multivariate analysis of OS identified 3 prognostic factors: WBC (P=0.028), age (P=0.002), and Efflux (P=0.005), while those of LFS identified 2 prognostic factors: age (P=0.021) and Efflux (P < 0.001). Efflux was the most reliable method in predicting an achievement of CR and stratifying the patients according to the prognosis in terms of OS and LFS in AML.

Original language	English
Pages (from-to)	63-70
Number of pages	8
Journal	Leukemia and Lymphoma
Volume	46
Issue number	1
DOIs	https://doi.org/10.1080/10428190400010759
State	Published - Jan 2005

Keywords

Acute myeloid leukemia
Cytogenetics
Daunorubicin efflux assay
Multidrug resistance

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10.1080/10428190400010759

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title = "Daunorubicin efflux assay in determining multidrug resistance of patients with acute myeloid leukemia",

abstract = "We evaluated the predictive value of mdr1 mRNA RT-PCR, P-glycoprotein (Pgp), and Daunorubicin efflux assays as regards achieving complete remission (CR), overall survival (OS), and leukemia-free survival (LFS) in 72 patients with AML. mdr1 mRNA, Pgp, and Efflux were expressed in 55.6%, 36.1%, and 33.3%. Efflux+ was associated with a lower CR rate (P=0.006). A multivariate analysis of OS identified 3 prognostic factors: WBC (P=0.028), age (P=0.002), and Efflux (P=0.005), while those of LFS identified 2 prognostic factors: age (P=0.021) and Efflux (P < 0.001). Efflux was the most reliable method in predicting an achievement of CR and stratifying the patients according to the prognosis in terms of OS and LFS in AML.",

keywords = "Acute myeloid leukemia, Cytogenetics, Daunorubicin efflux assay, Multidrug resistance",

author = "Kim, {Dong Hwan} and Lee, {Nan Young} and Kim, {Jong Gwang} and Sohn, {Sang Kyun} and Won, {Dong Il} and Suh, {Jang Soo} and Lee, {Gun Soo} and Chae, {Shung Chull} and Lee, {Kyu Bo}",

year = "2005",

month = jan,

doi = "10.1080/10428190400010759",

language = "English",

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pages = "63--70",

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T1 - Daunorubicin efflux assay in determining multidrug resistance of patients with acute myeloid leukemia

AU - Kim, Dong Hwan

AU - Lee, Nan Young

AU - Kim, Jong Gwang

AU - Sohn, Sang Kyun

AU - Won, Dong Il

AU - Suh, Jang Soo

AU - Lee, Gun Soo

AU - Chae, Shung Chull

AU - Lee, Kyu Bo

PY - 2005/1

Y1 - 2005/1

N2 - We evaluated the predictive value of mdr1 mRNA RT-PCR, P-glycoprotein (Pgp), and Daunorubicin efflux assays as regards achieving complete remission (CR), overall survival (OS), and leukemia-free survival (LFS) in 72 patients with AML. mdr1 mRNA, Pgp, and Efflux were expressed in 55.6%, 36.1%, and 33.3%. Efflux+ was associated with a lower CR rate (P=0.006). A multivariate analysis of OS identified 3 prognostic factors: WBC (P=0.028), age (P=0.002), and Efflux (P=0.005), while those of LFS identified 2 prognostic factors: age (P=0.021) and Efflux (P < 0.001). Efflux was the most reliable method in predicting an achievement of CR and stratifying the patients according to the prognosis in terms of OS and LFS in AML.

AB - We evaluated the predictive value of mdr1 mRNA RT-PCR, P-glycoprotein (Pgp), and Daunorubicin efflux assays as regards achieving complete remission (CR), overall survival (OS), and leukemia-free survival (LFS) in 72 patients with AML. mdr1 mRNA, Pgp, and Efflux were expressed in 55.6%, 36.1%, and 33.3%. Efflux+ was associated with a lower CR rate (P=0.006). A multivariate analysis of OS identified 3 prognostic factors: WBC (P=0.028), age (P=0.002), and Efflux (P=0.005), while those of LFS identified 2 prognostic factors: age (P=0.021) and Efflux (P < 0.001). Efflux was the most reliable method in predicting an achievement of CR and stratifying the patients according to the prognosis in terms of OS and LFS in AML.

KW - Acute myeloid leukemia

KW - Cytogenetics

KW - Daunorubicin efflux assay

KW - Multidrug resistance

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U2 - 10.1080/10428190400010759

DO - 10.1080/10428190400010759

M3 - Article

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AN - SCOPUS:12744281076

SN - 1042-8194

VL - 46

SP - 63

EP - 70

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 1

ER -

Daunorubicin efflux assay in determining multidrug resistance of patients with acute myeloid leukemia

Abstract

Keywords

UN SDGs

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