Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils

Justin W.A. Garyu; Kyoung Seong Choi; Dennis J. Grab; J. Stephen Dumler

doi:10.1128/IAI.73.2.1187-1190.2005

Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils

Justin W.A. Garyu, Kyoung Seong Choi, Dennis J. Grab, J. Stephen Dumler

Johns Hopkins University

Research output: Contribution to journal › Article › peer-review

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Abstract

Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.

Original language	English
Pages (from-to)	1187-1190
Number of pages	4
Journal	Infection and Immunity
Volume	73
Issue number	2
DOIs	https://doi.org/10.1128/IAI.73.2.1187-1190.2005
State	Published - Feb 2005

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10.1128/IAI.73.2.1187-1190.2005

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abstract = "Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.",

author = "Garyu, {Justin W.A.} and Choi, {Kyoung Seong} and Grab, {Dennis J.} and Dumler, {J. Stephen}",

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AU - Grab, Dennis J.

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AB - Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.

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Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils

Abstract

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