Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils

Justin W.A. Garyu; Kyoung Seong Choi; Dennis J. Grab; J. Stephen Dumler

doi:10.1128/IAI.73.2.1187-1190.2005

Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils

Justin W.A. Garyu
, Kyoung Seong Choi
, Dennis J. Grab
, J. Stephen Dumler

Johns Hopkins University

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.

Original language	English
Pages (from-to)	1187-1190
Number of pages	4
Journal	Infection and Immunity
Volume	73
Issue number	2
DOIs	https://doi.org/10.1128/IAI.73.2.1187-1190.2005
State	Published - Feb 2005

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10.1128/IAI.73.2.1187-1190.2005

Cite this

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title = "Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils",

abstract = "Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.",

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AU - Garyu, Justin W.A.

AU - Choi, Kyoung Seong

AU - Grab, Dennis J.

AU - Dumler, J. Stephen

PY - 2005/2

Y1 - 2005/2

N2 - Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.

AB - Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.

UR - https://www.scopus.com/pages/publications/12844260213

U2 - 10.1128/IAI.73.2.1187-1190.2005

DO - 10.1128/IAI.73.2.1187-1190.2005

M3 - Article

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AN - SCOPUS:12844260213

SN - 0019-9567

VL - 73

SP - 1187

EP - 1190

JO - Infection and Immunity

JF - Infection and Immunity

IS - 2

ER -

Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils

Abstract

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