TY - JOUR
T1 - Delivering Alcohol Neurotoxicity into Nucleus, When Clusterin Meets Bcl XL
T2 - A Commentary
AU - Suk, Kyoungho
PY - 2012/5
Y1 - 2012/5
N2 - The study by Kim and colleagues (in press) demonstrated that the expression of nuclear isoform of clusterin is induced by ethanol (EtOH) to participate in apoptotic cell death of neurons in developing rodent brain. EtOH-induced nuclear clusterin interacts with Bcl XL, thereby liberating proapoptotic Bax. This study indicates the proapoptotic role of nuclear clusterin in EtOH-exposed neurons, linking specific nuclear events to alcohol neurotoxicity. The study provides novel insights into the molecular mechanisms underlying fetal alcohol spectrum disorders.
AB - The study by Kim and colleagues (in press) demonstrated that the expression of nuclear isoform of clusterin is induced by ethanol (EtOH) to participate in apoptotic cell death of neurons in developing rodent brain. EtOH-induced nuclear clusterin interacts with Bcl XL, thereby liberating proapoptotic Bax. This study indicates the proapoptotic role of nuclear clusterin in EtOH-exposed neurons, linking specific nuclear events to alcohol neurotoxicity. The study provides novel insights into the molecular mechanisms underlying fetal alcohol spectrum disorders.
KW - Apoptosis
KW - Bcl-2 Family Proteins
KW - Clusterin
KW - Fetal Alcohol Spectrum Disorders
UR - http://www.scopus.com/inward/record.url?scp=84860491203&partnerID=8YFLogxK
U2 - 10.1111/j.1530-0277.2011.01670.x
DO - 10.1111/j.1530-0277.2011.01670.x
M3 - Article
C2 - 22142431
AN - SCOPUS:84860491203
SN - 0145-6008
VL - 36
SP - 745
EP - 747
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
IS - 5
ER -
