Design, synthesis and identification of novel colchicine-derived immunosuppressant

Dong Jo Chang; Eun Young Yoon; Geon Bong Lee; Soon Ok Kim; Wan Joo Kim; Young Myeong Kim; Jong Wha Jung; Hongchan An; Young Ger Suh

doi:10.1016/j.bmcl.2009.05.054

Design, synthesis and identification of novel colchicine-derived immunosuppressant

Dong Jo Chang, Eun Young Yoon, Geon Bong Lee, Soon Ok Kim, Wan Joo Kim, Young Myeong Kim, Jong Wha Jung, Hongchan An, Young Ger Suh

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A.

Original language	English
Pages (from-to)	4416-4420
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2009.05.054
State	Published - 1 Aug 2009

Keywords

Autoimmune disease
Colchicine
Cyclosporin A
Graft rejection
Immunosuppressant
Skin-allograft
Transplantation

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10.1016/j.bmcl.2009.05.054

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abstract = "Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A.",

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AU - Chang, Dong Jo

AU - Yoon, Eun Young

AU - Lee, Geon Bong

AU - Kim, Soon Ok

AU - Kim, Wan Joo

AU - Kim, Young Myeong

AU - Jung, Jong Wha

AU - An, Hongchan

AU - Suh, Young Ger

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KW - Colchicine

KW - Cyclosporin A

KW - Graft rejection

KW - Immunosuppressant

KW - Skin-allograft

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Design, synthesis and identification of novel colchicine-derived immunosuppressant

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