Design, synthesis and insight into the structure-activity relationship of 1,3-disubstituted indazoles as novel HIF-1 inhibitors

Hongchan An; Nam Jung Kim; Jong Wha Jung; Hannah Jang; Jong Wan Park; Young Ger Suh

doi:10.1016/j.bmcl.2011.08.120

Design, synthesis and insight into the structure-activity relationship of 1,3-disubstituted indazoles as novel HIF-1 inhibitors

Hongchan An, Nam Jung Kim, Jong Wha Jung, Hannah Jang, Jong Wan Park, Young Ger Suh

Seoul National University

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Design, synthesis and insight into the structure-activity relationship (SAR) of 1,3-disubstituted indazoles as novel HIF-1 inhibitors are described. In particular, the substituted furan moiety on indazole skeleton as well as its substitution pattern turns out crucial for the high HIF-1 inhibition.

Original language	English
Pages (from-to)	6297-6300
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	21
DOIs	https://doi.org/10.1016/j.bmcl.2011.08.120
State	Published - 1 Nov 2011

Keywords

Anti-cancer agent
HIF-1α
Hypoxia
SAR (structure-activity relationship)
YC-1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2011.08.120

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title = "Design, synthesis and insight into the structure-activity relationship of 1,3-disubstituted indazoles as novel HIF-1 inhibitors",

abstract = "Design, synthesis and insight into the structure-activity relationship (SAR) of 1,3-disubstituted indazoles as novel HIF-1 inhibitors are described. In particular, the substituted furan moiety on indazole skeleton as well as its substitution pattern turns out crucial for the high HIF-1 inhibition.",

keywords = "Anti-cancer agent, HIF-1α, Hypoxia, SAR (structure-activity relationship), YC-1",

author = "Hongchan An and Kim, {Nam Jung} and Jung, {Jong Wha} and Hannah Jang and Park, {Jong Wan} and Suh, {Young Ger}",

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AU - An, Hongchan

AU - Kim, Nam Jung

AU - Jung, Jong Wha

AU - Jang, Hannah

AU - Park, Jong Wan

AU - Suh, Young Ger

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Design, synthesis and insight into the structure-activity relationship (SAR) of 1,3-disubstituted indazoles as novel HIF-1 inhibitors are described. In particular, the substituted furan moiety on indazole skeleton as well as its substitution pattern turns out crucial for the high HIF-1 inhibition.

AB - Design, synthesis and insight into the structure-activity relationship (SAR) of 1,3-disubstituted indazoles as novel HIF-1 inhibitors are described. In particular, the substituted furan moiety on indazole skeleton as well as its substitution pattern turns out crucial for the high HIF-1 inhibition.

KW - Anti-cancer agent

KW - HIF-1α

KW - Hypoxia

KW - SAR (structure-activity relationship)

KW - YC-1

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DO - 10.1016/j.bmcl.2011.08.120

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 21

ER -

Design, synthesis and insight into the structure-activity relationship of 1,3-disubstituted indazoles as novel HIF-1 inhibitors

Abstract

Keywords

UN SDGs

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