Design, synthesis and insight into the structure-activity relationship of 1,3-disubstituted indazoles as novel HIF-1 inhibitors

Hongchan An, Nam Jung Kim, Jong Wha Jung, Hannah Jang, Jong Wan Park, Young Ger Suh

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Design, synthesis and insight into the structure-activity relationship (SAR) of 1,3-disubstituted indazoles as novel HIF-1 inhibitors are described. In particular, the substituted furan moiety on indazole skeleton as well as its substitution pattern turns out crucial for the high HIF-1 inhibition.

Original languageEnglish
Pages (from-to)6297-6300
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number21
DOIs
StatePublished - 1 Nov 2011

Keywords

  • Anti-cancer agent
  • HIF-1α
  • Hypoxia
  • SAR (structure-activity relationship)
  • YC-1

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