Designing smart microcapsules with polarity-selective and temperature-dependent permeability for drug delivery systems

Ji Won Kim, Sang Seok Lee, Shin Hyun Kim

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Microcapsule is a promising template to utilize as a drug carrier with their uniform membrane. However, microcapsules with size- and charge-selective permeability are still limited to introduce practical drugs, which usually have small sizes. Herein we report microfluidic approach to produce microcapsules with polarity-selective and temperature-dependent permeability using photo-curable monomers and phase change material. Through photo-polymerization, membrane can form continuous oil pathway within the rigid framework. Moreover, their pathway can be regulated additionally at different temperature. Therefore, it is believed to be improve as novel drug carrier with monodisperse shape, high encapsulation efficiency, high mechanical stability and selective permeability.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages1961-1963
Number of pages3
ISBN (Electronic)9781510897571
StatePublished - 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: 11 Nov 201815 Nov 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume4

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Country/TerritoryTaiwan, Province of China
CityKaohsiung
Period11/11/1815/11/18

Keywords

  • Drug carrier
  • Microcapsule
  • Permeability
  • Polarity
  • Temperature

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