Determination of correlation times of new paramagnetic gadolinium MR contrast agents by EPR and 17O NMR

Hee Kyung Kim; Gang Ho Lee; Tae Jeong Kim; Yongmin Chang

doi:10.5012/bkcs.2009.30.4.849

Determination of correlation times of new paramagnetic gadolinium MR contrast agents by EPR and 17O NMR

Hee Kyung Kim, Gang Ho Lee, Tae Jeong Kim, Yongmin Chang

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The work describes EPR and ¹⁷O NMR measurements followed by theoretical calculation of the rotational correlation time (τ_R), the water residence time (τ_m), and the longitudinal electronic spin relaxation time (T_1e) for two new gadolinium complexes 1 and 2 of the type [Gd(L)(H₂O)] (L = tranexamic esters) in order to investigate their efficiency as a paramagnetic contrast agent (PCA). Of three correlation times, τ_R plays a major and predominant role to the unusually high relaxivity of 1 and 2 as compared with that of clinically approved MR CAs such as [Gd(DTPA)(H₂O)]^2- (Magnevist^®), [Gd(DTPA-BMA)(H₂O)] (Omniscan^®), and [Gd(DOTA)(H₂O)]^- (Dotarem^®). The presence of bulky tranexamic ester in the ligand seems to be responsible for the conformational rigidity, which in turn causes such great an increase in τ_R.

Original language	English
Pages (from-to)	849-852
Number of pages	4
Journal	Bulletin of the Korean Chemical Society
Volume	30
Issue number	4
DOIs	https://doi.org/10.5012/bkcs.2009.30.4.849
State	Published - 2009

Keywords

Correlation times
Gadolinium chelate
MRI CA
Tranexamate

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title = "Determination of correlation times of new paramagnetic gadolinium MR contrast agents by EPR and 17O NMR",

abstract = "The work describes EPR and 17O NMR measurements followed by theoretical calculation of the rotational correlation time (τR), the water residence time (τm), and the longitudinal electronic spin relaxation time (T1e) for two new gadolinium complexes 1 and 2 of the type [Gd(L)(H2O)] (L = tranexamic esters) in order to investigate their efficiency as a paramagnetic contrast agent (PCA). Of three correlation times, τR plays a major and predominant role to the unusually high relaxivity of 1 and 2 as compared with that of clinically approved MR CAs such as [Gd(DTPA)(H2O)]2- (Magnevist{\textregistered}), [Gd(DTPA-BMA)(H2O)] (Omniscan{\textregistered}), and [Gd(DOTA)(H2O)]- (Dotarem{\textregistered}). The presence of bulky tranexamic ester in the ligand seems to be responsible for the conformational rigidity, which in turn causes such great an increase in τR.",

keywords = "Correlation times, Gadolinium chelate, MRI CA, Tranexamate",

author = "Kim, {Hee Kyung} and Lee, {Gang Ho} and Kim, {Tae Jeong} and Yongmin Chang",

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doi = "10.5012/bkcs.2009.30.4.849",

language = "English",

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journal = "Bulletin of the Korean Chemical Society",

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T1 - Determination of correlation times of new paramagnetic gadolinium MR contrast agents by EPR and 17O NMR

AU - Kim, Hee Kyung

AU - Lee, Gang Ho

AU - Kim, Tae Jeong

AU - Chang, Yongmin

PY - 2009

Y1 - 2009

N2 - The work describes EPR and 17O NMR measurements followed by theoretical calculation of the rotational correlation time (τR), the water residence time (τm), and the longitudinal electronic spin relaxation time (T1e) for two new gadolinium complexes 1 and 2 of the type [Gd(L)(H2O)] (L = tranexamic esters) in order to investigate their efficiency as a paramagnetic contrast agent (PCA). Of three correlation times, τR plays a major and predominant role to the unusually high relaxivity of 1 and 2 as compared with that of clinically approved MR CAs such as [Gd(DTPA)(H2O)]2- (Magnevist®), [Gd(DTPA-BMA)(H2O)] (Omniscan®), and [Gd(DOTA)(H2O)]- (Dotarem®). The presence of bulky tranexamic ester in the ligand seems to be responsible for the conformational rigidity, which in turn causes such great an increase in τR.

AB - The work describes EPR and 17O NMR measurements followed by theoretical calculation of the rotational correlation time (τR), the water residence time (τm), and the longitudinal electronic spin relaxation time (T1e) for two new gadolinium complexes 1 and 2 of the type [Gd(L)(H2O)] (L = tranexamic esters) in order to investigate their efficiency as a paramagnetic contrast agent (PCA). Of three correlation times, τR plays a major and predominant role to the unusually high relaxivity of 1 and 2 as compared with that of clinically approved MR CAs such as [Gd(DTPA)(H2O)]2- (Magnevist®), [Gd(DTPA-BMA)(H2O)] (Omniscan®), and [Gd(DOTA)(H2O)]- (Dotarem®). The presence of bulky tranexamic ester in the ligand seems to be responsible for the conformational rigidity, which in turn causes such great an increase in τR.

KW - Correlation times

KW - Gadolinium chelate

KW - MRI CA

KW - Tranexamate

UR - http://www.scopus.com/inward/record.url?scp=70349779221&partnerID=8YFLogxK

U2 - 10.5012/bkcs.2009.30.4.849

DO - 10.5012/bkcs.2009.30.4.849

M3 - Article

AN - SCOPUS:70349779221

SN - 0253-2964

VL - 30

SP - 849

EP - 852

JO - Bulletin of the Korean Chemical Society

JF - Bulletin of the Korean Chemical Society

IS - 4

ER -

Determination of correlation times of new paramagnetic gadolinium MR contrast agents by EPR and 17O NMR

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